中国耳鼻咽喉头颈外科2016，Vol.23Issue(10)：565-568,4.DOI:10.16066/j.1672-7002.2016.10.003
皮下免疫治疗对儿童变应性鼻炎患者血清人β防御素-2的影响观察
Effect of subcutaneous immunotherapy on serum levels of human beta defensin-2 in children with allergic rhinitis
摘要
Abstract
OBJECTIVE To investigate the effect of subcutaneousimmunotherapy(SCIT) on levels of the serum human beta defensin-2 in children with allergic rhinitis. METHODS 30 cases of children with allergic rhinitis who were treated by SIT were selected as the treatment group, 20 cases of healthy children as the control group. Serum HBD-2 concentration of the control group was tested. Serum HBD-2 concentration of the treatment group was tested at three different time points: before SCIT, half a year after SCIT and one year after SCIT. And total nasal symptom scores(TNSS) and medication scores were recorded at each time point. RESULTS The serum HBD-2 concentration of the control group, that of the treatment group before SIT, half a year after SIT and one year after SIT were 4.62[4.08; 4.87], 3.74[3.37; 4.61], 4.62[4.13; 5.54], 4.79[4.45;6.19]ng/ml. The HBD-2 concentration gradually increased after SCIT. The TNSS of the treatment group before SCIT, half a year after SCIT and one year after SCIT were 7.43±2.15, 4.17±2.16, 4.20±1.92, The medication scores of the treatment group before SCIT, half a year after SCIT and one year after SCIT were 1.25[0.75; 1.38], 0.25[0; 0.75, 0.25[0; 0.75].There was no correlation (all P>0.05) between the serum HBD-2 concentration and TNSS or medication scores of the treatment group. CONCLUSION The serum levels of HBD-2 in patients with allergic rhinitis were lower than those in normal persons. The specific immunotherapy raised the serum HBD-2 levels of allergic rhinitis patients.关键词
鼻炎,变应性,常年性/鼻炎,变应性,季节性/β防御素/脱敏法,免疫/儿童Key words
Rhinitis, Allergic, Perennial/Rhinitis, Allergic, Seasonal/beta-Defensins/Desensitization, Immunologic/Child引用本文复制引用
郑博,王淼,曾毅,刘凡理,叶余丰,项松洁,凡启军,叶建晓,倪丽艳..皮下免疫治疗对儿童变应性鼻炎患者血清人β防御素-2的影响观察[J].中国耳鼻咽喉头颈外科,2016,23(10):565-568,4.基金项目
温州市科技局面上项目（Y20130193）和国家卫生计生委国家临床重点专科（儿童呼吸专业）开放课题（20130105）联合资助 （）
