化工进展2016，Vol.35Issue(11)：3454-3458,5.DOI:10.16085/j.issn.1000-6613.2016.11.010
冻干过程在线气体质谱的研究
Study of online gas mass spectrometry for freeze-drying process
摘要
Abstract
In order to find an effective way to test the micro oil leakage and judge the end point of sublimation drying during the biochemical medicine vacuum freeze-drying process,the leakage of silicone oil in the lyophilizer and primary sublimation drying process online were monitored by mass spectrometer. The results showed that the original silicone oil quantity was 1×10–12 in the freeze-drying chamber tested by mass spectrometer.The mass spectrometer could test the leakage of silicone oil when the concentration was 1×10–6 in 15 minutes.With the lyophilizerno-load running, N2、O2、H2O、and Ar gas accounted for 82.31%、15.68%、1.37%、0.64% respectively. In the late period of medicine primary sublimation drying process,the four gases accounted for 82.47%、14.9%、1.75%、0.88% respectively. Each gas can be used tojudge the end of the medicine sublimation drying progress in a no-load freeze-drying chamber. The present study provides a new method for the judgement of silicone oil leakage and biochemical medicine primary freeze - drying progress.关键词
冻干过程/质谱仪/生化药品/硅油Key words
freeze-drying process/mass spectrometer/biochemical medicine/silicone oil分类
通用工业技术引用本文复制引用
唐树培,李保国,李俊奇,郭柏松..冻干过程在线气体质谱的研究[J].化工进展,2016,35(11):3454-3458,5.基金项目
上海市教委科研创新项目（14ZZ133）及上海市联盟计划（LM2014191）项目。 （）
