江汉大学学报（自然科学版）2016，Vol.44Issue(5)：422-426,5.DOI:10.16389/j.cnki.cn42-1737/n.2016.05.007
左旋四氢帕马丁对条件线索诱导的大鼠甲基苯丙胺复吸行为的影响
Effect of Levo-Tetrahydropalmatine on Methamphetamine-Seeking Behavior Induced by Conditioned Cues in Rats
摘要
Abstract
Objective To investigate effects of levo-tetrahydropalmatine( l-THP)on the reinstatement of methamphetamine induced by conditioned cues in rats. Methods Rats were trained to self-administer methamphetamine under fixed ratio 1(FR1)scheduler until stable responding was established. Follow⁃ing withdrawal(14d),rats randomly divided into four groups. Each group respectively received one dos⁃es of l-THP treatment(0 ,1. 25 ,2. 50 ,5. 00 mg/kg ,i. p.)and cues-induced methamphetamine seek⁃ing behavior was recorded. Results As compared with 0 mg/kg l -THP pretreatment group , l -THP (1. 25,2. 50,5. 00 mg/kg,i. p.)pretreatment group significantly decreased the number of active nose poke ( P < 0. 01). In contrast ,inactive nose poke had no significantly difference (all P > 0. 05). Conclusion l -THP(1. 25,2. 50,5. 00 mg/kg,i. p.)can inhibit the reinstatement of methamphet⁃amine induced by cues in rats.关键词
左旋四氢帕马丁/甲基苯丙胺/条件线索/复吸/大鼠Key words
levo-tetrahydropalmatine/methamphetamine/conditioned cues/reinstatement/rats分类
医药卫生引用本文复制引用
龚晓康,乐凯,马宝苗,干永平,金国章,李超英..左旋四氢帕马丁对条件线索诱导的大鼠甲基苯丙胺复吸行为的影响[J].江汉大学学报（自然科学版）,2016,44(5):422-426,5.基金项目
国家自然科学基金青年项目（81302762）；江汉大学研究生科研创新基金项目 （）
