畜牧与饲料科学2016，Vol.37Issue(10)：14-15,2.
广藿香对冰醋酸所致小鼠扭体疼痛模型的镇痛作用研究
Analgesic Effect of Pogostemon cablin on Acetic Acid-induced Writhing in Mice
摘要
Abstract
The aim of the present study was to assess the inhibitory effect of Pogostemon cablin on acetic acid-induced writhing in mice and to determine the analgesic effect of Pogostemon cablin. A total of 24 mice were randomly and averagely divided into Pogostemon cablin low-dose group, moderate-dose group, high-dose group and control group. The 0.25, 0.5, 1.0 g/(kg·BW) of Pogostemon cablin solutions were intragastricly administrated for the low-dose, moderate-dose and high-dose group, respectively, and saline was intragastricly administrated for the control group. The mice in treatment groups and control group subsequently received 20% of acetic acid solution by intragastric administration. The posture change and writhing times of the mice were recorded, and the analgesic rate was calculated. The results showed that after receiving 20%of acetic acid solution, the mice in high-dose group expressed mild abdominal pain symptoms and their counterparts in low-dose group exhibited severe symptoms and convulsed;the writhing times of high-dose group was very significantly less than that of low-dose group (P<0.01), and the writhing times of moderate-and low-dose group was significantly less than that of control group (P<0.05);the highest analgesic rate was observed in high-dose group (36.73%) and the lowest analgesic rate was observed in low-dose group (14.45%). The combined data showed Pogostemon cablin had inhibitory effect on acetic acid-induced writhing in mice, expressing good analgesic effect with exhibited dose-effect relationship.关键词
广藿香/冰醋酸/小鼠/镇痛/扭体试验Key words
Pogostemon cablin/acetic acid/mice/analgesia/writhing test分类
医药卫生引用本文复制引用
郭婷婷,崔一喆,钱榜,卢世超,王莹,武超..广藿香对冰醋酸所致小鼠扭体疼痛模型的镇痛作用研究[J].畜牧与饲料科学,2016,37(10):14-15,2.基金项目
黑龙江省大学生创新创业训练计划重点项目（201610223051）。 （）
