天然产物研究与开发2016，Vol.28Issue(9)：1343-1350,8.DOI:10.16333/j.1001-6880.2016.9.001
LC-MS导向分离灯心草中激动5-HT1A和MT2受体的活性成分
LC-MS-Guided Isolation of Chemical Constituents from Juncus effusus with 5-HT1A and MT2 Receptors-Agitating Activity
摘要
Abstract
Phytochemical studies on the active part of Juncus effusus resulted in the isolation of nine compounds using LC-MS and chromatographic techniques (Silica gel,Al2O3,Sephadex LH-20 and HPLC).Their structures were identified as effusol (1),dehydroeffusol (2),juncusol (3),juncuenin G (4),dehydrojuncuenin D (5),5-(hydroxymethyl)-l-methylphenanthrene-2,7-diol (6),oleanic acid (7),2-formyl-5-hydroxymethylfuran (8) and maltol-3-O-β-D-gluco-pyranoside (9) by HR-ESI-MS and NMR methods.Compounds 8 and 9 were obtained from the genus Juncus for the first time,and compound 9 was firstly isolated from natural resource.Compounds 1,3 and 4 showed significantly activity on 5-HT1A receptor with agitating rates of 65.35 ± 6.70％,71.33 ± 7.39％ and 64.11 ± 5.33％,and on MT2 receptor with agitating rates of 62.77 ± 12.06％,67.28 ± 9.26％ and 56.21 ± 11.43％ at the concentration of 1.0 mM.Compounds 2,5 and 6 possessed moderate activities agitating 5-HT1A and MT2 receptors.These results provided valuable information for the further study and utilization of J.effusus.关键词
灯心草/化学成分/5-HT1A受体/MT2受体/LC-MSKey words
Juncus effusus/chemical constituents/5-HT1A receptor/MT2 receptor/LC-MS分类
医药卫生引用本文复制引用
杨通华,耿长安,黄晓燕,马云保,颜得秀,陈纪军..LC-MS导向分离灯心草中激动5-HT1A和MT2受体的活性成分[J].天然产物研究与开发,2016,28(9):1343-1350,8.基金项目
中国科学院“百人计划” （）
