心理科学进展2016，Vol.24Issue(10)：1583-1591,9.DOI:10.3724/SP.J.1042.2016.01583
BDNF基因与抑郁
BDNF gene and depression
摘要
Abstract
It has been well documented that the etiology and development of depression have important genetic underpinnings.With the advancement of experimental methods of cellular and molecular biology and analysis techniques of molecular genetics,there is growing concern about BDNF gene,which relates to neural plasticity and found to be an important candidate gene of depression.Generally,existing studies had mainly explored the direct association between BDNF gene and depression,the interaction between BDNF gene and other genes,as well as the moderating effect of environmental factors on the association between BDNF gene and depression.However,the conclusions have been inconsistent and even contradictory in some cases.This might be due to the differences in research designs,indexes of environment measurement,methods of depression measurement,and participants' ethnic backgrounds of extant studies.Future research should focus on such issues as multiple gene-environment effects on depression,the moderation effect of participants' ethnicity,gender and age on the association between genes and depression,and the neural biological mechanisms underlying depression.关键词
BDNF基因/抑郁/基因-环境交互作用/神经营养因子假说Key words
BDNF gene/depression/gene-environment interaction/hypothesis of brain-derived neurotrophic factor分类
社会科学引用本文复制引用
田相娟,王美萍..BDNF基因与抑郁[J].心理科学进展,2016,24(10):1583-1591,9.基金项目
国家自然科学基金青年项目(31500899) （31500899）
山东师范大学优秀青年骨干教师国际合作培养项目 （）
山东师范大学青年科技培育基金项目 （）
山东师范大学发展与教育心理学重点学科建设经费资助项目. （）
