心理科学进展2016，Vol.24Issue(10)：1592-1599,8.DOI:10.3724/SP.J.1042.2016.01592
条件化恐惧复发的动物模型及相关神经机制
Animal models and related neurobiological mechanisms of conditioned fear relapse
摘要
Abstract
Post-traumatic stress disorder (PTSD) has received widespread concern at home and abroad.Exposure therapy,based on fear extinction,is commonly used in clinical practice.But the recurrence rate is still high after treatment.It suggests that the inhibition of fear relapse may be the key issue in the treatment of PTSD.Animal models of conditioned fear relapse include reinstatement,renewal,and spontaneous recovery,but most of the research has focused on renewal.Previous studies showed that fear relapse has heterogeneity,but the hippocampus,prefrontal cortex and amygdale may constitute common neural substrates.This article reviews brain region mechanisms and pharmacological intervention associated with conditioned fear relapse.It may provide reference for theoretical study and clinical treatment.关键词
恐惧复发/动物模型/消退/神经生物学机制Key words
fear relapse/animal models/extinction/neurobiological mechanisms分类
社会科学引用本文复制引用
付娟,郑希耕,刘正奎..条件化恐惧复发的动物模型及相关神经机制[J].心理科学进展,2016,24(10):1592-1599,8.基金项目
中国科学院知识创新工程项目(KSCX2-EW-J-8)、中国科学院重点部署项目(KJZD-EW-L04-2)、山东省自然科学基金项目(ZR2015CL025)、滨州市科学技术发展计划项目(2014ZC0328). （KSCX2-EW-J-8）
