摘要
Abstract
Objective To study the clinical effect and safety of high-frequency oscillatory ventilation (HFOV) combined with pulmonary surfactant (PS) in the treatment of neonatal severe meconium aspiration syndrome (MAS) complicated by neonatal pulmonary hemorrhage (NPH). Methods A total of 48 children with severe MAS complicated by NPH were enrolled, and a retrospective analysis was performed for the clinical effects of HFOV+PS (trial group, 25 children) and HFOV alone (control group, 23 children). The blood gas parameters, oxygenation index (OI), PaO2/FiO2 (P/F) value, duration of pulmonary hemorrhage, ventilation time, length of hospital stay, incidence of complications, and outcome were compared between the two groups. Results At 6, 12, 24, and 48 hours after treatment, the trial group had signiifcantly better PaO2, OI, and P/F value than the control group (P<0.05). Compared with the control group, the trial group had signiifcantly shortened ventilation time and duration of pulmonary hemorrhage (P<0.05). There were no signiifcant differences in the length of hospital stay, the incidence of complications, and cure rate between the two groups (P>0.05). Conclusions HFOV combined with PS can better improve oxygenation function and shorten the duration of NPH and ventilation time. Meanwhile, it does not increase the incidence of adverse events. Therefore, it is a safe and effective therapy.关键词
高频振荡通气/肺表面活性物质/胎粪吸入综合征/肺出血/新生儿Key words
High-frequency oscillatory ventilation/Pulmonary surfactant/Meconium aspiration syndrome/Pulmonary hemorrhage/Neonate
