中国当代儿科杂志2016，Vol.18Issue(11)：1094-1099,6.DOI:10.7499/j.issn.1008-8830.2016.11.008
人鼻病毒C型在呼吸道感染住院患儿中的流行病学研究
An epidemiological study on human rhinovirus C in hospitalized children with respiratory tract infections
李莉 1季伟 1邵雪君 1徐俊 1蒋吴君 1陈正荣 1唐汝泽 1严永东1
作者信息
- 1. 苏州大学附属儿童医院呼吸科，江苏苏州 215003
- 折叠
摘要
Abstract
Objective To investigate the detection rates, epidemical characteristics, and clinical features of human rhinovirus C (HRV-C) in hospitalized children with respiratory tract infections (RTIs) in Suzhou, China. Methods A total of 1 702 hospitalized children with RTIs from January to December, 2014 were enrolled, and 1 702 nasopharyngeal aspirate samples were collected from all children. RT-PCR was used to measure HRV mRNA, and quantitative real-time PCR combined with high-resolution melting curve was used to measure HRV-C. Results Of all children, 244 (14.34%) were detected to have HRV infection, among whom 69 (69/244, 28.3%) had HRV-C infection. The rate of mixed infection of HRV-C with other viruses and bacteria was 61%(42/69). HRV-C was detected in each month of the year, and the detection rate of HRV-C in autumn was signiifcantly higher than that in spring, summer, and winter (P<0.05). The children aged 2-5 years had a signiifcantly higher detection rate of HRV-C than those in the other age groups (P<0.05). Compared with HRV-A/B infection, HRV-C infection led to significantly higher proportions of patients with lobar pneumonia and acute exacerbation of asthma (P<0.05), as well as patients with increased neutrophil count and CRP level (P<0.05). There were no signiifcant differences in sex distribution or other clinical manifestations (P>0.05). Conclusions HRV-C infection accounts for about 1/3 of HRV infection, with a high incidence rate in autumn. The rate of mixed infection of HRV-C with other viruses and bacteria is high, and children aged 2-5 years have the highest detection rate of HRV-C. Children with HRV-C infection have similar clinical manifestations as those with HRV-A/B infection.关键词
鼻病毒/呼吸道感染/流行病学/儿童Key words
Rhinovirus/Respiratory tract infection/Epidemiology/Child引用本文复制引用
李莉,季伟,邵雪君,徐俊,蒋吴君,陈正荣,唐汝泽,严永东..人鼻病毒C型在呼吸道感染住院患儿中的流行病学研究[J].中国当代儿科杂志,2016,18(11):1094-1099,6.
