中国康复2016，Vol.31Issue(5)：358-361,4.DOI:10.3870/zgkf.2016.05.011
有氧运动对中年女性心肺功能和血管内皮功能的影响及其与雌激素的关系
Effects of aerobic exercise on cardiorespiratory fitness and endothelial function in middle aged women
杨洋 1李学宇 1冯杰莉 1赵威 1白瑾 1徐顺霖 1高炜 1郭丽君1
作者信息
- 1. 北京大学第三医院心内科，北京 100000
- 折叠
摘要
Abstract
Objective:To evaluate the effects of aerobic exercise on cardiorespiratory fitness and endothelial func-tion in middle aged women and whether these effects are related to the estrogen levels.Methods:In this test,a total of 45 healthy women aged 45-55 years were divided into exercise group (n = 31,including 1 5 postmenopausal women)and control group (20 subjects).The exercise group conducted a 12-weeks aerobic exercise,while the con-trol group had no exercise intervention.Each subject had taken cardiopulmonary exercise testing before and after 12 week with PVO2 reflecting the cardiorespiratory fitness.Plasma ADMA and NOS levels were measured to estimate endothelial function,and changes in plasma estrogen levels were also detected.Results:After 12 weeks,PVO2 and plasma NOS levels were increased,and plasma ADMA levels were decreased in exercise group as compared with the control group (P <0.05).However,there were no significant differences between premenopausal and postmenopa-usal women (P >0.05 ).Pearson correlation analysis showed the degrees of improvement in PVO2 was positively correlated with NOS (r=0.339,P =0.023),and negatively with ADMA (r=0.333,P =0.025).Both PVO2 and NOS had no correlation to baseline estrogen levels.Conclusion:The aerobic exercise training can significantly im-prove cardiorespiratory fitness in healthy middle-aged women and improve endothelial function as well.The increa-ses in the cardiorespiratory fitness may be related to the improvement of endothelial function.The improvement of endothelial function is not dependent on the basic estrogen level,suggesting that premenopausal and postmenopausal women get the same benefit from exercise.关键词
有氧运动/血管内皮细胞功能/心肺功能/雌激素Key words
aerobic exercise/endothelial function/cardiorespiratory fitness/estrogen分类
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杨洋,李学宇,冯杰莉,赵威,白瑾,徐顺霖,高炜,郭丽君..有氧运动对中年女性心肺功能和血管内皮功能的影响及其与雌激素的关系[J].中国康复,2016,31(5):358-361,4.
