中国比较医学杂志2016，Vol.26Issue(10)：14-18,5.DOI:10.3969.j.issn.1671-7856.2016.10.004
桃核承气汤对大鼠肝性脑病模型干预治疗的分析
Analysis of the preventive and therapeutic effects of Taohe Chengqi decoction on a rat model of hepatic encephalopathy
摘要
Abstract
Objective To analyze the preventive and therapeutic effects of a traditional Chinese medicine Taohe Chengqi decoction on a rat models of hepatic encephalopathy ( HE) induced by thioacetamide ( TAA) .Methods The rat model of HE was established by intraperitoneal injection of TAA,and the effects of Taohe Chengqi decoction were observed by neurobehavioral changes,neurological test,blood ammonia,serum biochemical indexes,and liver and brain pathological examination.Results The rat model of hepatic encephalopathy was successfully established.Low, medium and high dose Taohe Chengqi decoction markedly improved neuro-reflexes and liver and brain pathological damages, and significantly decreased the HE staging and serum biochemical indexes, and the results of high dose group was the best, similar to that of positive drug-treatment group.Conclusions Taohe Chengqi decoction exhibits promising preventive and therapeutic effects on the rat model of TAA-induced hepatic encephalopathy, and these results provide substantial experimetal evidence for its clinical application.关键词
桃核承气汤/肝性脑病/硫代乙酰胺/大鼠Key words
Taohe Chengqi decoction/Hepatic encephalopathy/Thioacetamide/Rat分类
医药卫生引用本文复制引用
李晓娟,余思邈,王睿林,李瑞生,朱云,王立福,杜宁,孙永强,宋雪艾,景婧,王丽苹,张帆..桃核承气汤对大鼠肝性脑病模型干预治疗的分析[J].中国比较医学杂志,2016,26(10):14-18,5.基金项目
国家“十二五”科技重大专项资助项目（2012zx10005010－002－002）。 （）
