中国医学创新2016，Vol.13Issue(27)：1-5,5.DOI:10.3969/j.issn.1674-4985.2016.27.001
静脉与关节腔内应用氨甲环酸减少全膝关节置换失血量的疗效对比
Effects of Intravenous Versus Intra-articular Tranexamic Acid on Reducing Blood Loss in Total Knee Arthroplasty of Contrast
摘要
Abstract
Objective:To compare the efficacy and safety of intravenous versus intra-articular Tranexamic Acid on reducing blood loss during the primary total knee arthroplasty(TKA).Method:From October 2013 to February 2016,181 cases of patients in our hospital were selected,randomly divided into three groups.The intravenous drip group was used intravenous drip TXA(≤1.2 g),intra-articular injection of the injected group was used of 50 mL 0.9% NS with 1.0 g TXA,intra-articular injection of the control group was used of 50 mL 0.9%NS.Each patient had negative pressure drainage after the drainage-tude clamped for 2 hours and received the blood routine examination and the blood coagulation indicator test,their daily drainage in the first three days was recorded postoperatively.The vein angiography of the lower limb was carried out within 7 days to observe the incidence of thrombosis.Result:Compared with the postoperative drainage,the total blood loss in both intravenous and intra-articular tranexamic aid,the intravenous drip group and the injected groups were less than that of the control group,the differences were statistically significant(P<0.001).Three groups of patients in the incidence of postoperative function of blood coagulation, thrombosis, and comparison of adverse events,the differences were no statistically significant(P>0.05).Conclusion:Both intravenous and intra-articular tranexamic aid are effective in reducing the postoperative blood loss in primary TKA without increasing the incidence of thrombosis but not significantly different.关键词
氨甲环酸/关节置换术/静脉滴注/关节腔内注射：失血Key words
Tranexamic Acid/Total knee arthroplasty/Intravenous drip/Intra-articular injection/Blood loss引用本文复制引用
杨伟臻,张剑锋,胡宝德,马志强,张立峰..静脉与关节腔内应用氨甲环酸减少全膝关节置换失血量的疗效对比[J].中国医学创新,2016,13(27):1-5,5.基金项目
2015年内蒙古医科大学第二附属医院院基金科研项目 （）
