中国医学创新2016，Vol.13Issue(27)：10-12,13,4.DOI:10.3969/j.issn.1674-4985.2016.27.003
局部晚期鼻咽癌TP方案诱导化疗及同期放化疗初步观察
Preliminary Research of TP-based Induction Chemotherapy and Concurrent Chemotherapy in the Treatment of Locally Advanced NPC
摘要
Abstract
Objective:To observe the adherence and adverse reactions of induction chemotherapy and different concurrent chemotherapy regimens for locally advanced nasopharyngeal carcinoma(NPC). Method:A total of 60 patients with locally advanced NPC were randomly divided into A,B,C groups,20 cases in each group.Group A was given TP-based induction chemotherapy,followed by concurrent chemoradiotherapy with cisplatin;Group B was given Cisplatin-based concurrent chemoradiotherapy.Group C was given TP-based concurrent radiochemotherapy.Radiotherapy was used by IMRT,GTVnx 68-72 Gy,GTVnd 65-70 Gy.The treatment compliance and incidence of adverse reactions of three groups were observed.Result:Group A,B and C completed the expected number of chemotherapy rates were 80.0%,95.0%,90.0%.Radiotherapy were completed at sufficient amount,compliance was good,the most common were gastrointestinal,oropharyngeal mucositis,myelosuppression,skin damage.In severe injuries differences were no statistical difference (P>0.05).But all adverse reactions rates were statistically different,group A was the highest,group B was the lowest,there was statistical significance(P<0.05).Conclusion:Locally advanced NPC treated by TP-based induction chemotherapy followed by cisplatin-based concurrent chemoradiotherapy,cisplatin-based concurrent radiochemotherapy,TP-based concurrent chemoradiotherapy,the compliance of treatment are good.The moderate and severe adverse reactions of the former is highest,cisplatin-based concurrent chemotherapy is lightest.关键词
局部晚期鼻咽癌/同期放化疗/诱导化疗/不良反应Key words
Locally advanced nasopharyngeal carcinoma/Concurrent chemoradiotherapy/Induction chemotherapy/Adverse reactions引用本文复制引用
李金伟,肖海,王蓉,曾红学..局部晚期鼻咽癌TP方案诱导化疗及同期放化疗初步观察[J].中国医学创新,2016,13(27):10-12,13,4.基金项目
赣州市科技局科技计划项目 （）
