中国医学创新2016，Vol.13Issue(27)：17-19,3.DOI:10.3969/j.issn.1674-4985.2016.27.005
大鼠罗哌卡因全身急性中毒研究
Study on Rats’ Systematic Acute Toxicity of Ropivacaine
摘要
Abstract
Objective:To observe the acute toxic effect of Ropivacaine and its lethal dose.Method:According to the pharmacology experiment of improved Karber's method,poisoning manifestations and deaths of rats given different dose of ropivacaine were observed and recorded.LD50 and 95% confidence interval were calculated according to LD50 of different groups.Result:When inserted Ropivacaine with blood dose of 2.6 mg/kg,the rats showed symptoms of convulsive induced contraction (convulsion),a loss of righting reflex,weakness of autonomic activities and respiratory depression without deaths.As the blood dose increased,the rats might die.When the blood dose reached 13.2 mg/kg,all the rats died.According to this research,lethal dose was between 2.6-12.6 mg/kg, whose LD50=7.29 mg/kg and 95%CI(5.88,8.70).After anatomy,the pathologic changes of the heart,liver, spleen,lung, kidney,intestines and stomach of the dead rats were given visual inspection.Conclusions:After a small dose of Ropivacaine into blood,the poisoning of central nervous system is reversible.A great dose of Ropivacaine causes reversible death.关键词
局麻药/罗哌卡因/急性毒性/LD50Key words
Local anesthetic/Ropivacaine/Acute toxicity/Lethal dose 50引用本文复制引用
杨军良,杨雄眺,郭宏财..大鼠罗哌卡因全身急性中毒研究[J].中国医学创新,2016,13(27):17-19,3.基金项目
广东省深圳市卫生局科技计划项目 （）
