孔连广 1曹杰智 1吕祥 1张洪涛 1王淡川 1麦伟锦 1冯锦杭 1植焕真 1苏刚岭 1郑祥珍1
作者信息
- 1. 广州市白云区中医医院 广东 广州 510470
- 折叠
摘要
Abstract
Objective:To research the influence of laparoscopic surgery on stress response,immune function,malignant biological behavior and life quality in treating rectal cancer.Method:From May 2011 to January 2013,70 cases of rectal cancer were divided into the observation group and the control group,each group had 35 cases.The observation group received laparoscopic surgery and the control group received conventional open surgery with a follow-up of 3 years.The differences of the short-term effects,the long-term effects, complication occurrence,changes of related clinical indexes before and after surgery and quality of life after surgery were compared.Result:There was no significant difference in the number of lymph node dissection of two groups(P>0.05),the operation time,bleeding volume,anal exhaust time and postoperative hospital stay of the observation group were lower than those of the control group,anus preservation rate was higher than that of the control group,the differences were statistically significant(P<0.05).The total complication rate of the observation group was 8.57%,which was lower than 31.43% of the control group,the difference was statistically significant (P<0.05).The tumor mortality rate,3 year cumulative survival rate and disease-free survival rate of the observation group were better than those of the control group,the differences were statistically significant(P<0.05). Two groups postoperative cortisol(COR),C-reactive protein(CRP),interleukin 6(IL-6) and interleukin 10(IL-10) levels were elevated,reduced glutathione(GSH),superoxide dismutase(SOD),tumor necrosis factor-α(TNF-α) andγ-interferon (INF-γ),vascular endothelial growth factor(VEGF) and acidic fibroblast growth factor(aFGF) and basic fibroblast growth factor(bFGF) levels were decreased,Cor,CRP,IL-6,IL-10,VEGF,aFGF and bFGF levels in the observation group were lower than those of the control group after operation, the GSH,SOD,TNF-α and INF-γwere higher than those of the control group,the differences were statistically significant(P<0.05).The postoperative quality of life in the observation group were higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion:Laparoscopic surgery has the advantages of remarkable effect,high safety,low stress reaction and immune suppression,helps to curb vicious biological behavior and improve the quality of life of patients,it is worthy of clinical promotion and application.关键词
腹腔镜/直肠癌/应激反应/免疫功能/恶性生物学行为/生活质量Key words
Laparoscopy/Rectal cancer/Stress response/Immune function/Malignant biological behavior/Life quality
