中国医学创新2016，Vol.13Issue(29)：6-8,9,4.DOI:10.3969/j.issn.1674-4985.2016.29.002
生长分化因子-15水平与急性冠脉综合征的相关性分析及其在预后中的价值
Serum Levels of GDF-15 in Acute Coronary Syndrom and Values in the Prognosis of Acute Coronary Syndrome
摘要
Abstract
Objective:To approach the relationship between the levels of growth differentiation factor-15 (GDF-15) and acute coronary syndrome(ACS),and combined with myocardial infarction three indicators(cTnI, CKMB,MYO) to assess the value in the prognosis of ACS.Method:A total of 106 hospitalized patients who were divided into two groups:ACS group(n=73) and the control group(n=33).ACS group was divided into three sub-groups such as low-risk group,mid-risk group and high-risk group according to Global Registry of Acute Coronary Events(GRACE) risk score.33 cases of patients excluded coronary artery disease by coronary arteriography were treated as the control group.Biochemical indicators such as cTnI,CK-MB,MYO were tested in all groups.The levels of GDF-15 were determined by antibody-sandwich enzyme-linked immunosorbent assay(ELISA).And the major adverse cardiac events(MACE) were followed up for one year.Result:Compared with the control group, the analysis showed that GDF-15 in ACS group and its sub-groups(low-risk group,mid-risk group and high-risk group) were significantly increased(P<0.01),GDF-15 increased obviously in high-risk group than low-risk group,mid-risk group(P<0.05).GDF-15 in ACS group had a positive correlation with GRACE risk score (r=0.57,P<0.01).GDF-15 was positively correlated with cTnI,CK-MB,and MYO(r=0.55,0.56,0.59, 0.54,P<0.01) in ACS group and its sub-groups.The occurrence rate of MACE in one year was greated elevated in ACS group compared with the control group(P<0.001).Conclusion:The levels of GDF-15 in ACS group an sub-groups are markedly increased,also had a positive correlation with GRACE risk score and myocardial infarction three indicators.It can be used to evaluate the occurrence and prognosis of MACE in one year of ACS.关键词
生长分化因子-15/急性冠脉综合征/肌钙蛋白/肌酸磷酸激酶同工酶/肌红蛋白Key words
Growth differentiation factor-15/Acute coronary syndrome/Troponin I/CKMB/MYO引用本文复制引用
金鸣锋,陈广华,周烨,丁澍,王翠平..生长分化因子-15水平与急性冠脉综合征的相关性分析及其在预后中的价值[J].中国医学创新,2016,13(29):6-8,9,4.基金项目
国家自然科学基金青年基金（81400269）；镇江市社会发展基金（SH2015041）；江苏大学临床医学专项基金 （）
