中国医学创新2016，Vol.13Issue(29)：13-16,4.DOI:10.3969/j.issn.1674-4985.2016.29.004
右美托咪啶对单肺通气患者中性粒细胞NF-κB活性及TNF-α、IL-8和IL-10水平的影响
Effects of Dexmedetomidine on NF-κB Activity of Polymorphonuclear Neutrophils,TNF-α,IL-8 and IL-10 during one Lung Ventilation in Patients Undergoing Electronic Thoracoscope Esophageal Cancer Radical Resection
摘要
Abstract
Objective:To observe the effects of Dexmedetomidine on NF-κB activity of polymorphonuclear neutrophils,TNF-α,IL-8 and IL-10 expression in one lung ventilation(OLV) patients.Method:Forty electronic thoracoscope esophagus cancer radical resection patients were divided randomly into two groups:the control group(C group,n=20) and Dexmedetomidine group(D group,n=20).5 milliliter radial artery blood was abstracted at the beginning of OLV(T0),30 min(T1),90 min(T2) after the beginning of OLV,30 min(T3),4 h(T4) and 24 h(T5) after one lung ventilation finished.NF-κB activity was measured in ELISA and expression of TNF-α,IL-10 and IL-8 were tested in ELISA.Alveolar-arterial blood oxygen difference[P(A-a)O2] and respiratory index(RI) were also recorded at the same time.Result:The value of NF-κB activity rised after T1,the peak value of NF-κB activity was got T3.NF-κB activity in D group was lower than that of C group at all time points after T0.Expression of TNF-α,IL-8 and IL-10 rised in two groups at T2,T3, T4 and T5.TNF-α and IL-8 expression in C group were higher than those in D group on T1,T2,T3,T4 and T5.But IL-10 expression in C group was lower than that in D group at the same time.The value of P(A-a)O2 and RI showed a progressive rise after T0.The value of P(A-a)O2 and RI in C group were higher than those in D group after T0.Conclusion:Dexmedetomidine can reduce the activity of NF-κB and then reduce the expression of TNF-α and IL-8.Dexmedetomidine can reduce inflammatory reaction during OLV and shows positive pulmonary protection.关键词
右美托咪啶/单肺通气/中性粒细胞/核因子-κB/TNF-α/IL-8/IL-10/食管癌Key words
Dexmedetomidine/One lung ventilation/Polymorphonuclear neutrophils/NF-κB/TNF-α/IL-8/IL-10/Esophagus cancer引用本文复制引用
李喜龙,邓巧荣,张震,卢锡华,崔亚萍..右美托咪啶对单肺通气患者中性粒细胞NF-κB活性及TNF-α、IL-8和IL-10水平的影响[J].中国医学创新,2016,13(29):13-16,4.基金项目
河南省高等学校重点科研项目 （）
