中国医学创新2016，Vol.13Issue(30)：1-6,7,7.DOI:10.3969/j.issn.1674-4985.2016.30.001
人附睾分泌蛋白4在子宫内膜癌组织中的表达及临床意义
Expression and Clinical Significance of Human Epididymis Secretory Protein 4 in Endometrial Carcinoma
摘要
Abstract
Objective:Through the detection of human epididymis secretory protein 4(HE4) expression in endometrial carcinoma and correlation study of HE4 and different clinical and pathological features,explore the diagnosis of endometrial cancer,the clinical significance of the treatment and prognosis.Method:The paraffin embedded specimens of 32 cases of endometrial carcinoma were confirmed by pathological examination,they were detected by using the two step method of immunohistochemical staining for HE4.The relations of the expression of HE4 in endometrial carcinoma and FIGO staging,pathological type,histological grade,myometrial invasion, tumor size and age differences between groups were analyzed,and its relationship with clinicopathological features of endometrial carcinoma was analyzed.Result:(1)HE4 positive particles were mainly localized in the cell membrane and cytoplasm,and the positive expression rate of HE4 in 32 cases of endometrial carcinoma was higher,which was 87.5%.(2)The positive expression rate and intensity of HE4 in the endometrial carcinoma tissues of the high differentiation group were higher than those in the low and middle differentiation group(P<0.05). (3)The positive expression rate and the expression intensity of HE4 protein in advanced endometrial carcinoma were higher than those in the early stage(P<0.05).(4)The positive expression of HE4 protein in endometrial carcinoma was not related to the age,pathological type, depth of invasion and tumor size(P>0.05),but in the HE4 positive expression level,deep myometrial invasion strong positive expression(61.5%) than no deep myometrial invasion(36.8%),the diameter of the tumor was greater than 2 cm strong positive expression(61.1%) is higher than the diameter <2 cm tumor(28.6%),the differences were statistically significant (P<0.05). Conclusion:The high expression of HE4 gene is closely related with the invasion and progression of endometrial carcinoma,it can be used as a marker for the progression of tumor invasion and an important index of evaluating the prognosis of endometrial carcinoma.关键词
人附睾分泌蛋白4/子宫内膜癌/免疫组化法/预后Key words
Human epididymis secretory protein 4/Endometrial carcinoma/Immunohistochemical method/Prognosis引用本文复制引用
孙润蛟,金仙玉,刘桂香,王文建,刘言厚,高言国..人附睾分泌蛋白4在子宫内膜癌组织中的表达及临床意义[J].中国医学创新,2016,13(30):1-6,7,7.基金项目
辽宁省大连市医学研究科研课题 （）
