肿瘤防治研究2016，Vol.43Issue(10)：883-886,4.DOI:10.3971/j.issn.1000-8578.2016.10.011
部分切除术与根治术治疗pT1bN0M0期肾癌的临床疗效对比
Clinical Outcomes of pT1bN0M0 Renal Cell Carcinoma: Partial Versus Radical Nephrectomy
邓康俐 1李有元 1崔殿生 1刘三河 1魏少忠1
作者信息
- 1. 430079武汉,湖北省肿瘤医院泌尿外科
- 折叠
摘要
Abstract
Objective To compare the clinical outcomes and prognosis of partial nephrectomy (PN) and radical nephrectomy (RN) on pTlbN0M0 renal cell carcinoma (RCC) patients,and to provide reference for treatment selection on pT1b RCC.Methods We retrospectively analyzed the data of 68 patients (PN=16 cases,RN=52 cases) diagnosed as pT1bN0M0 RCC from January 2004 to December 2010 in Hubei Cancer Hospital.We compared the clinical outcomes including 5-year overall survival (OS),recurrence-free survival (RFS) and cancer-specific survival (CSS) between two groups.We also analyzed renal function by collecting creatinine and estimated glomerular filtration rate(eGFR) before and after the operation.Results The 5-year OS (90.3％ vs.88.6％,P=0.552),RFS (90.3％ vs.75.4％,P=0.121) and CSS (90.3％ vs.92.8％,P=0.875) between PN and RN groups were not significantly different.The number of patients with a decrease of renal function was fewer in the PN group than that in the RN group (0 vs.12.6％,P＜0.01).However,the serum creatinine and GFR one year after surgery was not significantly different between two groups [(0.2±0.1) vs.(0.3 ±0.6),9=0.115,(9.8±12.1) vs.(20.1±12.6),P=0.064].Conclusion There was no significant difference in the clinical outcomes and safety between PN and RN on pTlbN0M0 RCC patients,moreover,postoperative renal function of PN group were better than those of RN group.PN could be an appropriate and safe option for pTlb RCC.关键词
肾癌/部分切除术/肾功能/预后Key words
Renal cell carcinoma/Partial nephrectomy/Renal function/Prognosis分类
医药卫生引用本文复制引用
邓康俐,李有元,崔殿生,刘三河,魏少忠..部分切除术与根治术治疗pT1bN0M0期肾癌的临床疗效对比[J].肿瘤防治研究,2016,43(10):883-886,4.
