肿瘤药学2016，Vol.6Issue(5)：321-325,5.DOI:10.3969/j.issn.2095-1264.2016.05.01
肠道微生态失衡与结肠炎相关肠癌发生发展的研究进展
Research Progress of the Dysbiosis of Gut Microbiota in the Pathogenesis of Colitis-associated Cancer
摘要
Abstract
It is increasingly perceived that patients with inflammatory bowel diseases (IBD) manifesting as a chronic relapsing intestinal inflammation would progress to colitis-associated cancer (CAC) ultimately. Aberrant immune responses, the dysbiosis of gut microbiota and the regeneration of epithelium play critical roles in the pathogenesis of CAC. In this re-view, the alteration of gut microbiota composition in the process from IBD to CAC was delineated. The significance of gut microbiota in the pathogenesis of CAC was discussed and moreover some interventions targeting gut microbiota to prevent CAC were summarized.关键词
炎症性肠病/结肠炎相关肠癌/肠道微生态Key words
Inflammatory bowel disease/Colitis-associated cancer/Gut microbiota分类
医药卫生引用本文复制引用
金多晨,曹海龙,董文逍,鄢芳,王邦茂..肠道微生态失衡与结肠炎相关肠癌发生发展的研究进展[J].肿瘤药学,2016,6(5):321-325,5.基金项目
国家自然科学基金（81470796，81570478）。 （）
