肿瘤药学2016，Vol.6Issue(5)：356-360,5.DOI:10.3969/j.issn.2095-1264.2016.05.07
血清TP、TS、DPD表达与SOX方案治疗晚期胃癌疗效的相关性
Correlation of the Serum TP, TS and DPD Expression with the Clinical Efficacy of Advanced Gastric Cancer Patients Treated by SOX Chemotherapy Regimen
摘要
Abstract
Objective To investigate the correlation between expressions of serum thymidylate synthase (TP), thymi-dylate phosphorylase (TS) and dihydropyrimidine dehydrogenase (DPD) expression and effects of S-1 chemotherapy in ad-vanced gastric cancer patients. Methods The serum samples of patients with advanced gastric cancer were selected before chemotherapy, and their TP, TS and DPD expression levels were detected by enzyme-linked immunosorbent assay (ELASA). Then their correlations were analyzed with the efficacy of chemotherapy. Results The advanced gastric cancer patients with low (negative) serum TS expression had higher effective rate after chemotherapy than those with high serum TS expression (77.78%vs. 28.57%, P<0.05). Patients with high (positive) serum TP expression had higher effective rate than those with low TP expression (66.67%vs. 25%, P<0.05). And patients with low expression of DPD in serum had higher effective rate than those with high DPD expression (62.5%vs. 21.43%, P<0.05). Conclusion The expression levels of TS, TP and DPD in serum of advanced gastric cancer patients were correlated with the clinical efficacy of SOX chemotherapy. Patients with negative TS and DPD and positive TP could get better efficacy after SOX chemotherapy.关键词
晚期胃癌/替吉奥/胸苷酸合成酶(TP)/胸苷酸磷酸化酶(TS)/二氢嘧啶脱氢酶(DPD)/化疗疗效Key words
Advanced gastric cancer/S-1/Thymidylate synthase/Thymidylate phosphorylase/Dihydropyrimidine de-hydrogenase/Chemotherapy分类
医药卫生引用本文复制引用
廖景升,陈镜塘,李壮华,贾筠,罗志荣..血清TP、TS、DPD表达与SOX方案治疗晚期胃癌疗效的相关性[J].肿瘤药学,2016,6(5):356-360,5.基金项目
2015年广东省东莞市科技计划一般项目（项目编号201510515000371）。 （）
