肿瘤药学2016，Vol.6Issue(5)：366-369,4.DOI:10.3969/j.issn.2095-1264.2016.05.09
经皮肝胆管穿刺引流术后卡培他滨联合调强放疗治疗胆管癌所致阻塞性黄疸的临床研究
A Clinical Study on Capecitabine Combined with IMRT plus Percutaneous Bile Duct Puncture in the Treatment of Bile Duct Cancer-Induced Obstructive Jaundice
王书山 1李瑞卿 1叶静 1周长杰1
作者信息
- 1. 泰安市肿瘤医院放疗科，山东泰安，271000
- 折叠
摘要
Abstract
Objective To evaluate the clinical effect of capecitabine(Cap) combined with intensity modulated radiation therapy (IMRT) on bile duct cancer-induced obstructive jaundice(MOJ) after percutaneous bile duct puncture(PTCD). Methods In this study, 42 patients with malignant obstructive jaundice due to bile duct cancer in our hospital bewteen March 2011 and May 2014 were randomly divided into two groups, 21 cases in each group. The treatment method of the study group was PTCD+Cap+IMRT, while it was PTCD+IMRT in the con-trol group. The curative effects were observed and compared between the two groups. Results The study group achieved a high effective rate of 80.9%, which was significantly higher than that of the control group of 66.7%(P<0.05). The survival rates of the study group were respectively 80.95%(17/21), 57.14%(12/21) and 38.10%(8/21) at 6 months, 12 months and 18 months after treatment. Whereas the survival rates were respectively 71.43%(15/21), 47.62%(10/21) and 14.28%(3/21) in the control group. There were no significant differences in the survival rate at 6th and 12th month between the two groups(P>0.05), but the survival rate at 18th month was significantly higher in the study group than in the control group(P<0.05). The adverse reactions, such as gastrointestinal reaction and bone marrow suppression, had no sta-tistical differences between the two groups(P>0.05). Conclusion By using the method of percutaneous puncture, capecitabine combined with intensity modulated radiation therapy could significantly relieve the symptoms of jaundice, and achieve a better effect on patients with malignant obstructive jaundice. This method deserves clinical application.关键词
胆管穿刺/卡培他滨/调强放疗/胆管癌/阻塞性黄疸Key words
Bile duct puncture/Capecitabine/Intensity modulated radiation therapy/Bile ductcancer/Obstructive jaundice分类
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王书山,李瑞卿,叶静,周长杰..经皮肝胆管穿刺引流术后卡培他滨联合调强放疗治疗胆管癌所致阻塞性黄疸的临床研究[J].肿瘤药学,2016,6(5):366-369,4.
