安徽医科大学学报2016，Vol.51Issue(11)：1630-1633,4.DOI:10.19405/j.cnki.issn1000-1492.2016.11.017
α-硫辛酸对急性冠脉综合征患者心肌损伤保护作用的研究
The protective effects of α-lipoic acid on myocardial injury of acute coronary syndrome patients
摘要
Abstract
Objective To investigate the protective effects of α-lipoic acid (α-LA) on myocardial injury of acute coronary syndrome patients. Methods 59 patients with acute coronary syndrome were randomized into two groups:conventional treatment group and α-LA group. 29 patients in conventional treatment group received routine drugs, while 30 patients inα-LA group were givenα-LA (600 mg/d, IVD, for 3 days) besides routine drugs. The activi-ty of ALDH2,level of MDA and LDH of serum in all patients were separately detected by microtitration,TBA and ELISA before and after treatment ( 24, 72 hours ),LVEF values were analyzed by UCG. Results ①There were no significant differences between the two groups before treatment. ②After 24 h and 72 h treatment, the activity of ALDH2 in two groups were increased ( P<0. 01 ) and the level of MDA was decreased ( P<0. 01 ) compared to the data before treatment. Compared to after 24 h, the level of LDH was reduced after 72 h (P<0. 01) and the LVEF values were significantly higher after 72 h and 1 week (P<0. 05). ③Compared to conventional treatment group, the activity of ALDH2 inα-LA group was significantly increased ( P<0. 01 ) and the levels of MDA and LDH were decreased after 24 h and 72 h ( P<0. 05 , P<0. 01 ) . The LVEF values were significantly increased after 1 week (P<0. 05). Conclusion α-LA may increase the ALDH2 activity, reduce peroxidation end product (MDA) gen-eration of serum in ACS patients, and finally decline oxidative damage to myocardial ischemia and reperfusion ( the level of LDH decreased) .关键词
急性冠脉综合征/α-硫辛酸/乙醛脱氢酶2/丙二醛/乳酸脱氢酶Key words
acute coronary syndrome/α-lipoic acid/ALDH2/MDA/lactate dehydrogenase分类
医药卫生引用本文复制引用
杨翠翠,丁旵东,操全霞..α-硫辛酸对急性冠脉综合征患者心肌损伤保护作用的研究[J].安徽医科大学学报,2016,51(11):1630-1633,4.基金项目
安徽省卫生厅医学科研课题计划(编号:2010C058) （编号:2010C058）
