吉林医药学院学报2016，Vol.37Issue(6)：428-429,430,3.
1-甲基-3-丙基-4-硝基吡唑-5-甲酰胺的合成优化
The optimal synthesis of 1-methyl-3-propyl-4-nitro pyrazole-5-formamide
摘要
Abstract
Objective To optimize the synthetic process of 1-methyl-3-propyl-4-nitro pyrazole-5-formamide.Meth-ods Using toluene as solvent ,and using the single factor text and orthogonal design to optimize the dosage of toluene solvent.Results The optimal conditions were as follows:10.9 equivalent toluene(a),3.6 equivalent toluene(b), 7.3 equivalent toluene(c).The yield was 96.7%.Conclusion The results showed that the product stability and yield was improved by the optimized synthetic process which was suitable for scale -up production .关键词
1-甲基-3-丙基-4-硝基吡唑-5-甲酰胺/合成优化/正交设计Key words
1-methyl-3-propyl-4-nitro pyrazole-5-formamide/synthetic optimization/orthogonal design分类
医药卫生引用本文复制引用
张林豪,罗苗,刘廷廷,李彬彬,宋泽文,梁承武..1-甲基-3-丙基-4-硝基吡唑-5-甲酰胺的合成优化[J].吉林医药学院学报,2016,37(6):428-429,430,3.基金项目
吉林市科技计划项目（2015131007）；吉林省科技发展计划项目（20140311110YY）． （）
