发育医学电子杂志2016，Vol.4Issue(3)：158-161,4.
麒麟丸对卵巢储备功能减退患者体外受精-胚胎移植的影响
Effect of Qi Lin Wan applied to patients with diminished ovarian reserve treated by in vitro fertilization and embryo transfer
摘要
Abstract
Objective To discuss the effect of Qi Lin Wan applied to patients treated by in vitro fertilization and embryo transfer (IVF-ET) with diminished ovarian reserve (DOR).MethodsFrom January 2013 to March 2015, 120 patients with DOR who were going to receive in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) were enrolled in Center for Reproductive Medicine, Shanghai Changzheng Hospital, Second Military Medical University. Patients were randomly divided into traditional Chinese medicine group and control group, 60 cases in each group. On the third day of menstrual cycle, the patients in control group were given routine mild stimulation. The patients in traditional Chinese medicine group took Qi Lin Wan orally for 2 months before menstrual cycle, and continued to take Qi Lin Wan after entering cycle and received the routine mild stimulation until the trigger. All patients received frozen-thawed embryo transfer of replacement cycle. The age, years of infertility, basal level of follicle stimulating hormone (FSH) and estradiol, antral follicle count (AFC), dose of gonadotropin (Gn), days of super ovulation, number of retrieved oocytes, number of embryos and rate of pregnancy in the two groups were analyzed. TheChi-square test and pairedt test were used for statistical analysis.ResultsThe average age of 120 patients was (38.5±2.3) years, years of infertility were 1~20 years. 52 cases were primary infertility and 68 cases were secondary infertility. The basal level of FSH in traditional Chinese medicine group was lower than that in control group[(9.2±3.2) vs (11.0± 3.4) U/L,t=2.034,P<0.05], and AFC were higher than those in control group[(7.4±2.7) vs (6.1±2.1),t =2.001,P<0.05]. Although there were no statistical differences in days of super ovulation and dose of Gn (P>0.05), the number of retrieved oocytes in traditional Chinese medicine group was higher than that in control group[(4.4± 2.2) vs (3.3± 2.2),t=2.132,P<0.05). So was the rate of pregnancy[53.3% (32/60) vs 46.7% (28/60),χ2=2.819,P<0.05)].Conclusion The adjuvant therapy of Qi Lin Wan can improve the ovarian reserve function of DOR patients, improve ovarian response and the outcomes of IVF-ET treatment.关键词
麒麟丸/体外受精-胚胎移植/卵巢储备功能下降/冻融胚胎移植Key words
Qi Lin Wan/In vitro fertilization and embryo transfer/Diminished ovarian reserve/Frozen-thawed embryo transfer引用本文复制引用
徐晨,王亮,李文,孙宁霞,章青,庞文娟,曹燕..麒麟丸对卵巢储备功能减退患者体外受精-胚胎移植的影响[J].发育医学电子杂志,2016,4(3):158-161,4.基金项目
国家自然科学基金面上项目 （）
