口腔疾病防治2016，Vol.24Issue(11)：634-639,6.DOI:10.12016/j.issn.2096-1456.2016.11.003
骨保护素对去卵巢大鼠中种植体骨整合的影响
Effects of osteoprotegerin on implant osseointegration in ovariectomized rats
摘要
Abstract
Objective To investigate the role of osteoprotegerin (OPG) in implant osseointegration in ovariecto⁃mized rats. Methods 12 weeks after bilateral ovariectomy, each rat accepted 2 titanium screws in the proximal tibiae. All animals were then randomly divided into 2 groups:control (10 rats) and OPG group (10 rats). Subcutaneous injection of OPG (10 mg/kg) or vehicle was performed 3 times a week. 8 weeks later, tibiae with screws were harvested for μCT, histological and biomechanical analysis. Results Compared to control, OPG increased the percent bone volume by 124%, the percent osseointegration by 167%, the mean trabecular number by 111%, the mean trabecular thickness by 92%, the mean connective density by 95%; and decreased the mean trabecular separation by 64% in μCT analysis. OPG also increased bone area density by 160%and bone⁃to⁃implant contact by 234%in histomorphometric evaluation, and increased the maximal push⁃out force by 228% in biomechanical test. Conclusion Systemic administration of OPG can improve implant osseointegration and fixation in ovariectomized rats, resulting from the increased peri⁃implant bone mass and improved trabecular microarchitecture.关键词
种植体/骨整合/骨质疏松/骨保护素/大鼠Key words
Implant/Osseointegration/Osteoporosis/Osteoprotegerin/Rat分类
医药卫生引用本文复制引用
刘显文,张超,刘曙光,艾伟健,周会喜,李运峰..骨保护素对去卵巢大鼠中种植体骨整合的影响[J].口腔疾病防治,2016,24(11):634-639,6.基金项目
国家自然科学基金（81300858）；广东省医学科学技术研究基金项目 （）
