国际医药卫生导报2016，Vol.22Issue(21)：3240-3242,3.DOI:10.3760/cma.j.issn.1007-1245.2016.21.008
HBeAg阴性慢性乙型肝炎患者在核苷(酸)类抗病毒药物治疗3年HBsAg定量的动态变化及其停药前水平对持续病毒学应答的预测作用
Antiviral nucleotide-induced dynamic change of HBsAg quantity over 3-year follow-up and the prognostic value of HBsAg level prior to drug-withdrawal for sustained viral response in patients with chronic hepatitis B negative for HBeAg
摘要
Abstract
Objective To analyze antiviral nucleotide-induced dynamic change of HBsAg quantity over 3-year follow-up during the period of sustained viral response and the prognostic value of HBsAg level prior to drug-withdrawal for sustained viral response in patients with chronic hepatitis B negative for HBeAg.Methods 115 patients with chronic hepatitis B negative for HBeAg were treated with antiviral nucleotide.HBsAg quantity was measured every half year,and the dynamic change of 3-year was analyzed.35 patients withdrew nucleotide successively 3 years later,they were followed up 1 more year to observe the persistence of curative effect after drug-withdrawal.The relationship between HBsAg quantity at point of drug-withdrawal and the persistence of curative effect was analyzed.Results HBsAg quantity of 115 patients with chronic hepatitis B negative for HBeAg decreased gradually with the prolongation of antiviral therapy in 3-year follow-up period (F=3.01,P＜0.05).HBsAg quantity at baseline was (3.13±0.79) logIU/ml,and those after 6,12,18,24,30,36 months were (3.11±0.86),(3.06±0.85),(2.98±0.92),(2.91±0.84),(2.83±0.82),(2.76±0.95) logIU/ml respectively (compared with the baseline,t =0.18,0.65,1.33,2.05,2.83,3.21,P=0.85,0.52,0.19,0.04,0.005,0.002).After drug-withdrawal,HBsAg quantity in the group of sustained off-treatment virological response (n=13) and the group of virological recurrence (n=22) were (2.21±0.73),(2.89±0.95) logIU/ml (t=2.03,P=0.03).Conclusions HBsAg quantity of patients with chronic hepatitis B negative for HBeAg decreased with prolongation of antiviral therapy.The patients who had lower HBsAg quantity at point of drug-withdrawal had better persistence of curative effect after drug-withdrawal.关键词
慢性乙型肝炎/肝炎表面抗原/核苷(酸)类抗病毒药/持续病毒学应答Key words
Chronic hepatitis B/Hepatitis B surface antigen/Nucleotide (acid) antivirus drug/Sustained off-treatment virological response引用本文复制引用
高洪波,牛易,施海燕,邓浩辉,关玉娟..HBeAg阴性慢性乙型肝炎患者在核苷(酸)类抗病毒药物治疗3年HBsAg定量的动态变化及其停药前水平对持续病毒学应答的预测作用[J].国际医药卫生导报,2016,22(21):3240-3242,3.基金项目
广州市医药卫生科技项目(201102A213207)Guangzhou Medicine and Health Science and Technology Project (201102A213207) （201102A213207）
