摘要
Abstract
Objective To study the clinical effect of different blood purification methods in the treatment of uremic pruritus.Methods 150 cases of uremic pruritus in our hospital were randomly divided into HD group,HD+HDF group,HPD group with the draw,50 cases in each group.Compared the pruritus score,the changes of serum calcium,blood urea nitrogen (BUN),serum phosphorus,PTH,β2-MG levels among three groups before and 3 months after treatment.Results There was no statistically significant difference in the pruritus score among three groups before treatment (P＞0.05);1,3 months after treatment,the pruritus score in HD+HDF group,HPD group were significantly lower than that in HD group (P＜0.05).There were no statistically significant differences in serum calcium,BUN levels among three groups after treatment (P＞0.05);serum phosphorus,PTH,β2-MG levels in HD+HDF group were respectively (l.56±0.72)mmoi/L,(34.72±10.36) pmol/L,(33.26±11.85)mg/L,those in HPD group were respectively (1.54±0.70)mmol/L,(33.26±11.85)pmol/L,(12.35±5.67)mg/L,without statistically significant differences between two groups (P＞0.05),those in HD+HDF group,HPD group were significantly lower than those in HD group,with statistically significant differences (P＜0.05).Conclusions HD+HDF and HPD are both effective methods for the treatment of uremic pruritus.The clinical treatment should be optimized to the blood purification methods of clearing small,medium and larg,e molecular substances.关键词
血液净化/尿毒症/皮肤瘙痒Key words
Blood purification/Uremia/Pruritus
