摘要
Abstract
Objective To investigate the application effect of trimetazidine during percutaneous coronary intervention (PCI) in patients with unstable angina pectoris.Methods 88 patients with unstable angina peetoris treated with PCI were randomly divided into control group (44 eases) and observation group (44 cases).Control group was treated with aspirin,clopidogrel,and atorvastatin,and observation group was treated with trimetazidine on the basis of routine treatment in control group.Compared the clinical effect,serum creatine kinase (CK),creatine kinase isoenzyme (CK-MB),cardiac troponin-T (cTnT) before and after treatment between two groups,and evaluated the coronary blood flow with TIMI frames.Results The clinical total effective rate of observation group was 88.64％,significantly higher than 75％ of control group,with statistically significant difference (P＜0.05).The levels of serum CK,CK-MB,and cTnT in observation group after surgery were (82.31±22.46) U/L,(14.32±±2.67) U/L,(0.05±0.07) ng/ml,significantly lower than (102.34±29.58) U/L,(19.29±3.45) U/L,(0.13±0.11) ng/ml in control group,with statistically significant differences (P＜0.05).The TFC value of anterior descending,circumflex branch,right coronary artery,and the average TFC value in observation group were significantly lower than those in control group,with statistically significant differences (P＜0.05).Conclusion Trimetazidine can effectively alleviate myocardial injury and improve coronary artery blood flow in patients with unstable angina pectoris during PCI,with clinical promotion value.关键词
曲美他嗪/不稳定型心绞痛/经皮冠状动脉介入治疗/围术期Key words
Trimetazidine/Unstable angina pectoris/Percutaneous coronary intervention/Perioperative period
