高校化学工程学报2016，Vol.30Issue(5)：999-1006,8.DOI:10.3969/j.issn.1003-9015.2016.05.003
喜树碱在二甲亚砜和甲醇（或乙醇）混合溶剂中溶解度的测定和关联
Measurement and Correlation of Camptothecine Solubility in Dimethylsulfoxide-Methanol/Ethanol Mixed Solvents
摘要
Abstract
Camptothecine solubility in dimethylsulfoxide-methanol/ethanol mixed solvents was measured over temperature range of 274.50~326.00 K under atmospheric pressure. The experimental results show that the solubility of camptothecine in the mixed solvents increases with the increase of temperature and dimethylsulfoxide mole fraction. The experimental solubility data are well correlated with a modified Apelblat equation, λh equation and ideal equation, respectively. The Akaike’s Information Criterion (AIC) was used to select the best model for correlation. The dissolution enthalpy, entropy and Gibbs free energy change of camptothecine are calculated using the measured solubility.关键词
喜树碱/溶解度/固液相平衡/热力学参数Key words
camptothecine/solubility/solid-liquid equilibrium/thermodynamic properties分类
生物科学引用本文复制引用
支娟娟,徐家阔,刘琼,李涛,任保增..喜树碱在二甲亚砜和甲醇（或乙醇）混合溶剂中溶解度的测定和关联[J].高校化学工程学报,2016,30(5):999-1006,8.基金项目
河南技术突破重大项目(112101210200)。 （112101210200）
