海南医学院学报2016，Vol.22Issue(21)：2595-2598,4.DOI:10.13210/j.cnki.jhmu.20160831.008
维胺酯胶囊联合消银颗粒对银屑病患者血清VEGF、TNF、NO、白细胞介素及T细胞亚群的影响
Effect of viaminate capsule combined with Xiaoyin particles on serum VEGF,TNF,NO,in-terleukins and T lymphocyte subsets in patients with psoriasis
摘要
Abstract
Objective:To study the effect of viaminate capsule combined with Xiaoyin particles on serum VEGF,TNF, NO,interleukins and T lymphocyte subsets in patients with psoriasis.Methods A total of 90 patients with psoriasis in our hos-pital from May 2014 to May 201 6 were enrolled in this study.The subjects were divided into the control group (n =45)and the treatment group (n =46)randomly.The control group were treated with viaminate capsule,the treatment group were treated with viaminate capsule combined with Xiaoyin particles.The two groups were treated for 3 months.The serum VEGF,TNF-α,NO,IL-6,IL-8,IL-1βlevels and peripheral blood CD4 + and CD8 + cells of the two groups before and after treatment were compared.Results There were no significantly differences of the serum VEGF,TNF-α,NO,Interleukins (IL-6,IL-8,IL-1β) levels and peripheral blood CD4 + ,CD8 + and CD4 +/CD8 + cells of the two groups before treatment (P > 0.05 ).The serum VEGF,TNF-α,NO,Interleukins (IL-6,IL-8,IL-1β)levels of the two groups after treatment were significantly lower than before treatment (P <0.05),and that of treatment group were significantly lower than the control group (P <0.05).The pe-ripheral blood CD4 + and CD4 +/CD8 + cells of the two groups after treatment were significantly higher than before treatment (P <0.05),CD8 + cells of the two groups after treatment were significantly lower than before treatment (P <0.05),the pe-ripheral blood CD4 + and CD4 +/CD8 + cells of the treatment group after treatment were significantly higher than that of the control group (P <0.05),but there was no significantly differences in the peripheral blood CD8 + cells of the two groups after treatment (P >0.05).Conclusions Viaminate capsule combined with Xiaoyin particles can significantly reduce the serum VEGF, TNF-α,NO,IL-6,IL-8 and IL-1βlevels,improve the T lymphocyte subgroup levels of the patients with psoriasis,and it was worthy clinical application.关键词
银屑病/维胺酯胶囊/消银颗粒/血管内皮生长因子/肿瘤坏死因子/一氧化氮/白细胞介素/T淋巴细胞亚群Key words
Weizhian capsule/Xiaoyin particles/Psoriasis/VEGF/TNF/NO/Interleukins/T lymphocyte subsets分类
医药卫生引用本文复制引用
赵萍,贾天剑,林江..维胺酯胶囊联合消银颗粒对银屑病患者血清VEGF、TNF、NO、白细胞介素及T细胞亚群的影响[J].海南医学院学报,2016,22(21):2595-2598,4.基金项目
江苏省自然科学基金课题资助(BK2012287)@@@@Project supported by the Natural Science Foundation of Jiangsu Province：BK2012287． （BK2012287）
