海南医学院学报2016，Vol.22Issue(22)：2677-2680,4.DOI:10.13210/j.cnki.jhmu.20160814.025
丁苯酞联合阿司匹林、氯吡格雷抗血小板治疗进展性脑梗死的神经保护作用研究
Neuroprotective effect of butylphthalide combined with aspirin and clopidogrel antiplatelet therapy for progressive cerebral infarction
摘要
Abstract
[ABSTRACT]Objective:To analyze the neuroprotective effects of butylphthalide combined with aspirin and clopidogrel an-tiplatelet therapy for progressive cerebral infarction.Methods:A total of 86 patients with progressive cerebral infarction were randomly divided into observation group and control group (n=43),control group received aspirin and clopidogrel antiplatelet therapy,observation group received butylphthalide combined with aspirin and clopidogrel antiplatelet therapy,and then the differences in platelet function,blood coagulation function,middle cerebral artery blood flow state and nerve function index lev-els were compared between two groups after treatment.ResuIts:After 1 course of treatment,the relative content of P-selectin and GPⅡb/Ⅲa on platelet surface as well as TXB2,vWF and D-D content in plasma of observation group were significantly lower than those of control group,while 6-Keto-PGF1αcontent in plasma was significantly higher than that of control group;thrombelastogram indexes R and K value were higher than those of control group while MA,Angle and CI value were lower than those of control group;middle cerebral artery PSV,EDV,Vm and PI were higher than those of control group while RI value was lower than that of control group;nerve function indexes BDNF and H2 S content in plasma were higher than those of control group while NSE,MBP,S100B and MMP-9 content were lower than those of control group (P<0.05).ConcIusion:Butylphthalide combined with aspirin and clopidogrel antiplatelet therapy can effectively optimize the platelet and blood coagula-tion function in patients with progressive cerebral infarction,promote the middle cerebral artery blood flow recovery and exert positive neuroprotective effect.关键词
进展性脑梗死/丁苯酞/抗血小板/神经保护Key words
Progressive cerebral infarction/Butylphthalide/Antiplatelet/Neuroprotection分类
医药卫生引用本文复制引用
何兴兵..丁苯酞联合阿司匹林、氯吡格雷抗血小板治疗进展性脑梗死的神经保护作用研究[J].海南医学院学报,2016,22(22):2677-2680,4.基金项目
陕西省科技攻关项目(2013JM4053)@@@@This study was supported by key project of Shaanxi provincial science and technology research foundation (grant No ．2013jm4053)． （2013JM4053）
