海南医学院学报2016，Vol.22Issue(22)：2724-2727,2731,5.DOI:10.13210/j.cnki.jhmu.20160814.023
α-硫辛酸联合甲钴胺治疗对糖尿病神经源性膀胱患者尿流动力学及神经氧化损伤程度的影响
Effect ofα-lipoic acid combined with mecobalamine therapy on urodynamics and oxidative damage of nerve in patients with diabetic neurogenic bladder
摘要
Abstract
[ABSTRACT]Objective:To analyze the effect ofα-lipoic acid combined with mecobalamine therapy on urodynamics and oxidative damage of nerve in patients with diabetic neurogenic bladder.Methods:A total of 78 patients with diabetic neurogenic bladder were randomly divided into observation group and control group (n=39),control group received conventional therapy and observation group received conventional therapy +α-lipoic acid combined with mecobalamine therapy.Before treatment and after one course of treatment,urodynamic indexes,peripheral nerve conduction latency time and serum indexes of two groups were detected respectively.ResuIts:After one course of treatment,RUV,Pdet,FS,T and C value as well as ROS, MDA,SP,NPY and ChAT content of both groups were significantly lower than those before treatment,MFR value as well as GSH,SOD,BDNF and CNTF content was significantly higher than those before treatment,and the sensory conduction latency time of median nerve and ulnar nerve as well as motor conduction latency time of median nerve and peroneal nerve were shorter than those before treatment (P<0.05);RUV,Pdet,FS,T and C value as well as ROS,MDA,SP,NPY and ChAT content of observation group were significantly lower than those of control group,MFR value as well as GSH,SOD,BDNF and CNTF content was significantly higher than those of control group,and the sensory conduction latency time of median nerve and ulnar nerve as well as motor conduction latency time of median nerve and peroneal nerve were significantly shorter than those of con-trol group (P<0.05).ConcIusion:α-lipoic acid combined with mecobalamine therapy can optimize the urodynamics in patients with diabetic neurogenic bladder and also reduce the oxidative damage of nerve,and it is an effective solution for treatment of such disease.关键词
2 型糖尿病/神经源性膀胱/α-硫辛酸/甲钴胺/尿流动力学/氧化损伤Key words
Type 2 diabetes/Neurogenic bladder/α-lipoic acid/Mecobalamine/Urodynamics/Oxidative damage分类
医药卫生引用本文复制引用
叶明宝,杜昌国,燕群峰,桂佳梅..α-硫辛酸联合甲钴胺治疗对糖尿病神经源性膀胱患者尿流动力学及神经氧化损伤程度的影响[J].海南医学院学报,2016,22(22):2724-2727,2731,5.基金项目
陕西省科技攻关基金资助项目(2013-SF2-14)@@@@[FoundationProject]This study was supported by Shaanxi provincial science and technology research foundation (grant No ．2013- SF 2-14) （2013-SF2-14）
