海南医学院学报2016，Vol.22Issue(22)：2739-2741,3.DOI:10.13210/j.cnki.jhmu.20160831.001
肝素对脊柱创伤PCS椎弓根螺钉术后患者血流变学及炎症细胞因子的影响
Effect of heparin on the hemorheology and inflammatory cytokines in patients with spinal trauma after PCS pedicle screw fixation
摘要
Abstract
[ABSTRACT]Objective:To explore the effect of low molecular weight heparin (LMWH)on the hemorheology,inflamma-tory cytokines,and coagulation funtion in patients with spinal trauma after PCS pedicle screw fixation.Methods:A total of 80 patients with spinal trauma who were admitted in our hospital were included in the study and randomized into the treatment group and the control group with 40 cases in each group.The patients in the two groups were performed with PCS pedicle screw fixation.The patients in the treatment group were given subcutaneous inj ection of LMWH after operation.The hemorhe-ology indicators,inflammatory cytokines levels,and coagulation function change before and after operation in the two groups were compared.ResuIts:The comparison of RBV (low shear,middle shear,and high shear)(mPa��s),PAR,and PAR (1 min)(%)before operation between the two groups was not statistically significant (P>0.05),the above indicators 24 h after operation in the two groups were significantly elevated when compared with before operation (P<0.05),and the above indica-tors 24 h after operation in the treatment group were significantly lower than those in the control group (P<0.05).The above indicators 48 h and 1 week after operation in the control group were significantly elevated,while those in the treatment group were significantly reduced when compared with before treatment (P<0.05).CRP,IL-6,and IL-10 levels after operation in the treatment group were significantly lower than those in the control group (P<0.05).PT,APTT,and FIB after operation in the treatment group were significantly lower than those in the control group (P<0.05).ConcIusions:LMWH can effectively re-duce the blood viscosity,inhibit the inflammatory reaction,and contribute to postoperative rehabilitation in patients with spinal trauma after PCS pedicle screw fixation.关键词
脊柱创伤/PCS椎弓根螺钉/低分子肝素/血流变学/炎症细胞因子/凝血功能Key words
Spinal trauma/PCS pedicle screw fixation/LMWH/Hemorheology/Inflammatory cytokines/Coagula-tion funtion分类
医药卫生引用本文复制引用
黄南翔,林宏,李伟..肝素对脊柱创伤PCS椎弓根螺钉术后患者血流变学及炎症细胞因子的影响[J].海南医学院学报,2016,22(22):2739-2741,3.基金项目
四川省南充市科技局科学技术计划项目(15A0039)[FoundationProject]:ItwassupportedbytheScientificandTechnologicalPlanningProjectofNanchongScientificandTechnologicalBureauinSichuanProvince (NO．15A0039)． （15A0039）
