河北医学2016，Vol.22Issue(10)：1585-1587,1588,4.DOI:10.3969/j.issn.1006-6233.2016.10.001
替罗非班对ST段抬高心肌梗死后早期介入患者心肌灌注及心肾的影响
Function of Patients with ST-segment Elevation After Myocardial Infarction by Early Intervention
摘要
Abstract
Objective: To investigate the influence of tirofiban on patients with ST segment elevation myocardial perfusion and heart and kidney in ST-segment elevation myocardial infarctionly early intervention. Methods:100 patients with acute myocardial infarction admitted to our hospital from January 2015 to January 2016 were randomly divided into two groups, each with 50 cases. The control group was treated with low mo-lecular weight heparin, and the observation group was treated with low molecular weight heparin combined with tirofiban. The cardiac color doppler findings, intervention and post-intervention three days before brain natri-uretic peptide in renal function during the course of treatment and adverse reactions were compared before and after the intervention. Results:1 week after intervention, both the left ventricular end diastolic diameter and the left ventricular end systolic diameter were less than before intervention ( P<0.05) . The left ventricular e-jection fraction was greater than pre-intervention and post-intervention group, The left ventricular ejection fraction was greater than that in the control group ( P<0.05) . BNP levels in the observation group after inter-vention were lower than that in the control group (P<0.05). The levels of creatinine and urea nitrogen after one week intervention were lower than before intervention ( P<0.05) , and after one week intervention the level of serum creatinine and blood urea nitrogen in the observation group was lower than that in the control group after the intervention ( P<0.05) . The rate of gastrointestinal bleeding, bruising and skin the total proportion of fecal occult blood or the like significantly of observation group was lower than that in the control group ( P<0. 05) . Conclusion:Tirofiban on the patients with ST segment elevation myocardial infarction after early coro-nary intervention can significantly improve the myocardial perfusion and protect the heart and kidney function.关键词
替罗非班/ST段抬高心肌梗死/介入/心肌灌注/心功能/肾功能Key words
Tirofiban/ST segment elevation myocardial infarction/Intervention/Myocardial perfusion/Ventricular function/Renal function引用本文复制引用
丁红,徐丽丽..替罗非班对ST段抬高心肌梗死后早期介入患者心肌灌注及心肾的影响[J].河北医学,2016,22(10):1585-1587,1588,4.基金项目
四川省科技计划项目，(编号:2014SZ0235) （编号:2014SZ0235）
