河北医学2016，Vol.22Issue(10)：1595-1597,3.DOI:10.3969/j.issn.1006-6233.2016.10.005
美沙拉秦不同给药途径治疗活动期溃疡性结肠炎的疗效及对血清炎性因子的影响
Effects of Mesalazine by Different Administration Routes on Active Ulcerative Colitis and the Influence on Serum Inflammatory Factors
摘要
Abstract
Objective:To investigate the effects of mesalazine by different administration routes and ser-um levels of tumor necrosis factor ( TNF-α) , interleukin-10 ( IL-10) and interleukin-17 ( IL-17) in treat-ment of active ulcerative colitis ( UC) . Methods: Totally 60 eligible patients were selected and randomly di-vided into observation group and control group, with 31 patients in observation group and 29 patients in control group. The control group was given mesalazine sustained-release granules once for 1g; while the observation group was given mesalazine enemas once for 4g. After 4 weeks of treatment, the clinical efficacy was observed, and the serum levels of TNF-α, IL-10, and IL-17 were measured. Results:The observation group had sig-nificantly higher overall response rate than the control group (93.55% vs. 79.31%)(P<0.05).After treat-ment, both groups had significantly lower serum levels of TNF-αand IL-17 and significantly higher serum IL-10 level than those before treatment (P<0.05).The observation group had significantly greater improving ex-tents of serum levels of TNF-α, IL-10, and IL-17 than the control group ( P<0.05) . Conclusion: Mesala-zine used by enema in treatment of UC has a significant clinical efficacy, and it is beneficial to the balance be-tween inflammatory factors and antiinflammatory factors.关键词
溃疡性结肠炎/活动期/美沙拉秦/炎性因子Key words
Ulcerative colitis/Active phase/Mesalazine/Inflammatory factor引用本文复制引用
李晓玲..美沙拉秦不同给药途径治疗活动期溃疡性结肠炎的疗效及对血清炎性因子的影响[J].河北医学,2016,22(10):1595-1597,3.基金项目
四川省眉山市科技支撑计划项目，(编号:2013－016) （编号:2013－016）
