河北医学2016，Vol.22Issue(10)：1604-1607,4.DOI:10.3969/j.issn.1006-6233.2016.10.009
PTENmRNA和hTERTmRNA与子宫内膜样腺癌生物学行为关系的探讨
Investigating the Relationship of PTENmRNA and hTERTmRNA to the Biological Behavior in Endometrioid Adenocarcinoma
张桂香 1齐洁敏 2王闯 2赵学东 1庄新荣1
作者信息
- 1. 承德医学院附属医院，河北 承德 067000
- 2. 承德医学院病理教研室，河北 承德 067000
- 折叠
摘要
Abstract
Objective:To investigate the expression of PTENmRNA and hTERTmRNA in endometrioid adenocarcinoma, and evaluate the relationship of their expression to the biological behavior of endometrioid ad-enocarcinoma. Methods:The expression of PTENmRNA and hTERTmRNA of the 50 patients with endometri-oid adenocarcinoma and 50 patients with normal endometrium were observed by in situ hybridization, then e-valuated their influence to the biological behavior of endometrioid adenocarcinoma. Results: The positive ex-pression of PTENmRNA and hTERTmRNA were 30.0% and 78.0% respectively. The expression of PTENmR-NA and hTERTmRNA were correlated with tumor differentiation, FIGO staging, lymphnode metastasis and muscular infiltration of endometrioid adenocarcinoma(P<0.05). Conclusion: The expression of PTENmRNA and hTERTmRNA are related to the formation and development of endometrioid adenocarcinoma. Combined detection of PTENmRNA and hTERTmRNA expression can be used as an index to evaluate the malignant de-gree and prognosis of endometrioid adenocarcinoma.关键词
子宫内膜样腺癌/PTENmRNA/hTERTmRNA/原位杂交Key words
Endometrioid adenocarcinoma/PTENmRNA/hTERTmRNA/In situ hybridization引用本文复制引用
张桂香,齐洁敏,王闯,赵学东,庄新荣..PTENmRNA和hTERTmRNA与子宫内膜样腺癌生物学行为关系的探讨[J].河北医学,2016,22(10):1604-1607,4.
