河北医学2016，Vol.22Issue(10)：1607-1610,4.DOI:10.3969/j.issn.1006-6233.2016.10.010
叶酸对老年高血压病患者的临床疗效及对血浆同型半胱氨酸与血管内皮功能的影响
Clinical Efficacy of Folic Acid in Treating Senile Hypertension and Influence on Plasma Homocysteine Level and Vascular Endothelial Function
摘要
Abstract
Objective:To analyze the clinical efficacy of folic acid in treating senile hypertension and in-fluence on plasma homocysteine ( Hcy) level and vascular endothelial function. Methods:The data of 90 ca-ses with HTN treated in our hospital from February 2015 to February 2016 was retrospectively analyzed, and the patients were divided into two groups, the control group for 40 cases and the research group for 50 cases. The control group was treated with antihypertensive drugs, and the research group was treated with antihyper-tensive drugs combined with folic acid. The blood pressure, plasma Hcy level and vascular endothelial function of two groups before and after treatment was observed. Results: After treatment, the blood pressure, plasma Hcy level and vascular endothelial function of two groups reduced, but the research group was more evident than the control group, and the difference was evident, There's statistical significance( P<0.05) . ET-1 level of two groups reduced, and NO, EID and FMD level of two groups improved. The difference was evident, There's statistical significance( P<0.05) . But ET-1 level of the research group was lower than that of the con-trol group, There's statistical significance(P<0.05). Conclusion: Folic acid in treating senile hypertension can not only evidently reduce Hcy level, but also improve vascular endothelial function, which is worthy of clinical application and research.关键词
叶/酸/老年高血压/血浆同型半胱氨酸/血管内皮功能Key words
Folic acid/Senile hypertension/Plasma homocysteine/Vascular endothelial func-tion引用本文复制引用
陈锋,乔晋,张力..叶酸对老年高血压病患者的临床疗效及对血浆同型半胱氨酸与血管内皮功能的影响[J].河北医学,2016,22(10):1607-1610,4.基金项目
陕西省教育厅2012自然科学基金科研课题，(编号:12JK0707) （编号:12JK0707）
