河北医学2016，Vol.22Issue(10)：1615-1618,4.DOI:10.3969/j.issn.1006-6233.2016.10.013
辛伐他汀联合辅酶Q10对慢性心衰大鼠心功能及心室重构的影响
Effects of Simvastatin Combined CoenzymeQ10 on Ventricular Remodeling and Cardiac Function in Rats with CHF
摘要
Abstract
Objective:To investigate the effects of simvastatin combined coenzymeQ10 on ventricular re-modeling and cardiac function in rats with chronic heart failure ( CHF) . Methods:40 SD rats were randomly divided into five groups:sham-operated group, coenzymeQ10 group, simvastatin group, simvastatin combined coenzymeQ10 group and model group. Coarctation of abdominal aorta ( CCA) except for the shame-operated group. Testing hemodynamic of left ventricular end-diastolic diameter press (LVEDP),left ventricular pres-sure rise and fall ( ±dp/dtmax) ,left ventricular mass/body mass ( LVMI);HE and Masson’ s trichrome stai-ning for morphology. Results:Compared with model group, hemodynamic analysis revealed that left ventricu-lar end-diastolic pressure ( LVEDP ) were significantly lower in simvastatin group, coenzymeQ10, simvastatin combined coenzymeQ10 group(P<0.01), left ventricular pressure rise and fall increased remarkable(P<0.01);In addition, left ventricular mass/body mass ( LVMI) and collagen volume fraction ( CVF%) was de-creased sharply(P<0.01).CoenzymeQ10 group,simvastatin combined coenzymeQ10 groups improved CHF re-markable than rest groups (P< 0.05).Conclusion: All of these results verify that treatment with simvastatin combined coenzymeQ10 has more obvious effects on improving heart function of rats with cardiac remodeling and inhibit ventricular remodeling.关键词
辛伐他汀/辅酶Q10/慢性心力衰竭/心室重塑/心功能Key words
Simvastatin/CoenzymeQ10/CHF/Ventricular remodeling/Cardiac function引用本文复制引用
于海荣,张秀芝,王济兴,吕博杰,陈建双..辛伐他汀联合辅酶Q10对慢性心衰大鼠心功能及心室重构的影响[J].河北医学,2016,22(10):1615-1618,4.基金项目
河北省承德市科学技术研究与发展计划项目，(编号:20151082) （编号:20151082）
