河北医学2016，Vol.22Issue(10)：1731-1733,1734,4.DOI:10.3969/j.issn.1006-6233.2016.10.064
葛根芩连汤治疗对2型糖尿病湿热证肠道菌群影响
Effect of Intestinal Flora of Type 2 Diabetes Patients with Dampness-heat Syndrome Treated with Gegen Qinlian Decoction
摘要
Abstract
Objective:To observe the effect of Gegen Qinlian Decoction in treating type 2 diabetes pa-tients with dampness-heat syndrome and the effect of intestinal flora. Methods:Forty-two type 2 diabetes pa-tients with damp-heat syndrome were randomly divided into 2 groups:the control group was treated with West-ern medicine alone, and the experimental group was treated with integrated Traditional and Western medicine. The fecal samples were collected to extract bacterial genome DNA, and the composition was investigated by Il-lumina Miseq high-throughput sequencing of the V3 region of the 16S rRNA gene. Species in feces were also measured by real-time quantitative PCR. The relationship between effectiveness and gut microbiota was ob-served after treatment. Results: The total effectiveness of experimental group was higher than that of control group. Bacteroides correlated negatively with the reduction rate of dampness-heat syndrome, while Fusobacte-rium correlated positively with the reduction rate of dampness-heat syndrome. Conclusion:The combination of Gegen Qinlian Decoction with Western medicine has the effective treatment among type 2 diabetes patients with dampness-heat syndrome, and Bacteroides and Fusobacterium could be the markers of effectiveness.关键词
湿热证/2型糖尿病/肠道菌群/葛根芩连汤Key words
Dampness-heat syndrome/Type 2 diabetes/Gut microbiota/Gegen Qinlian De-coction引用本文复制引用
曾艺鹏,冯新格,谷成英,郭亚芳,许迎烈..葛根芩连汤治疗对2型糖尿病湿热证肠道菌群影响[J].河北医学,2016,22(10):1731-1733,1734,4.基金项目
上海市浦东新区科技发展基金项目，(编号:PKJ2012－Y20)；上海市浦东新区传统型中医临床示范学科建设项目，(编号:PDZXK－3－2013009) （编号:PKJ2012－Y20）
