临床口腔医学杂志2016，Vol.32Issue(11)：684-686,3.DOI:10.3969/j.issn.1003-1634.2016.11.014
沙利度胺对复发性阿弗他溃疡患者外周血淋巴细胞亚群的影响
Observation the effect of Thalidomide treatment of recurrent aphthous ulcers on peripheral lymphocyte popula-tions
罗志晓 1艾俊 1陈明月 1冷卫东1
作者信息
- 1. 十堰市太和医院口腔医学中心，湖北医药学院附属医院 湖北 十堰 442000
- 折叠
摘要
Abstract
Objective:To observe the clinical efficacy of Thalidomide in the treatment of Recurrent Aphthous Ulcers ( RAU) and its impact on subsets of lymphocytes in the peripheral circulation.Methods:Thalidomide was administered to 85 patients with RAU minor at 25 mg per day.The clinical effect was measured by comparing the remission time and the number of ulcers pre-and post-intervention.Meanwhile,the total number of peripheral lymphocytes and the ratio of CD4 +T cell to CD8 +T cells were measured before and after the intervention compared with the control group consisted of health partici-pants.Results:Compared to the control group,there was a significant decrease of CD4 +T cells and increase of CD8 +T cells (P<0.05)in the patients with RAU minor before the treatment.The ratio of the two subsets was also abnormal.After the in-tervention,the ratio of the lymphocyte subsets was improved.Meanwhile,there was a significant increase in the remission time of the ulcers and reduced in the number of ulcers in patient group(P<0.05).Conclusion:The ratio of the peripheral lym-phocyte subsets is abnormal in patients with RAU.Thalidomide has a significant effect in correcting the abnormal ratio of CD4 +T cells to CD8 +T cells.It can also increase the remission time of ulcers and reduce the frequency of ulcer breakouts. The clinical efficacy has been satisfactory.关键词
复发性阿弗他溃疡/沙利度胺/淋巴细胞亚群/疗效Key words
Recurrent aphthous ulcers/Thalidomid/Lymphocyte populations/Clinical efficacy分类
医药卫生引用本文复制引用
罗志晓,艾俊,陈明月,冷卫东..沙利度胺对复发性阿弗他溃疡患者外周血淋巴细胞亚群的影响[J].临床口腔医学杂志,2016,32(11):684-686,3.
