器官移植2016，Vol.7Issue(6)：459-462,483,5.DOI:10.3969/j.issn.1674-7445.2016.06.009
脐带间充质干细胞治疗难治性慢性移植物抗宿主病的疗效观察
Clinical efficacy of umbilical cord-derived menchymal stem cell treatment of refractory chronic graft-versus-host disease
张玲 1张祥忠 1李晓青 1龙冰 1林东军 1李旭东1
作者信息
- 1. 510630 广州，中山大学附属第三医院血液科
- 折叠
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of umbilical cord-derived mesenchymal stem cell (MSC ) treatment of refractory chronic graft-versus-host disease (cGVHD ) after allogene hematopoietic stem cell transplantation. Methods Seven patients developed with cGVHD following allogene hematopoietic stem cell transplantation. Conventional immunosuppressive agent treatment yielded no efficacy. Based upon immunosuppressive agent therapy,umbilical cord-derived MSC treatment was supplemented with a cell density of 1 ×1 06/kg,once a week for consecutive 4 times. Clinical efficacy,safety and survival of the patients were observed. Results Among 7 patients receiving MSC injection,2 obtained complete response (CR)and 3 had partial response (PR)with an overall response rate of 5/7,and the remaining 2 cases achieved no response (NR). No adverse reactions were induced by MSC injection. No patient had primary disease recurrence. One patient developed secondary cytomegalovirus pneumonia after PR and died from severe pneumonia. The remaining patients survived. Conclusions Umbilical cord-derived MSC injection is an efficacious and safe therapy of cGVHD.关键词
脐带/间充质干细胞/慢性移植物抗宿主病/造血干细胞移植Key words
Umbilical cord/Mesenchymal stem cell/Chronic graft-versus-host disease/Hematopoietic stem cell transplantation分类
医药卫生引用本文复制引用
张玲,张祥忠,李晓青,龙冰,林东军,李旭东..脐带间充质干细胞治疗难治性慢性移植物抗宿主病的疗效观察[J].器官移植,2016,7(6):459-462,483,5.
