山东医药2016，Vol.56Issue(42)：17-20,4.DOI:10.3969/j.issn.1002-266X.2016.42.005
CYP2D6基因多态性对接受他莫昔芬治疗ER 阳性乳腺癌患者预后的影响
Effects of CYP2D6 gene polymorphism on prognosis of ER-positive breast cancer patients treated with tamoxifen therapy
摘要
Abstract
Objective To discuss the effects of cytochrome P4502D6 (CYP2D6)gene polymorphism on prognosis of estrogen receptor (ER)-positive breast cancer patients treated with tamoxifen (TAM)therapy.Methods From May 2010 to May 2012,CYP2D6 genotype was detected in 106 cases of ER-positive breast cancer patients treated with TAMtherapy by PCR.The relationship between CYP2D6 polymorphism and clinical parameters and prognosis were analyzed by χ2 test and Logistic regression model.Results In 106 cases of ER-positive breast cancer patients treated with TAM therapy,48 cases of Wt/Wt type accounted for 45.3%,42 cases of Wt/*10 type accounted for 39.6%,and 16 cases of *10 /*10 type accounted for 15.1%.χ2 test showed CYP2D6 genotype was not significantly correlated with age (χ2 =0.391,P =0.822),tumor size (χ2 =2.544,P =0.280),histology (χ2 =3.600,P =0.165),TNMstage (χ2 =2.785,P =0.246) and axillary lymph node metastasis (χ2 =2.997,P =0.223).Logistic regression model showed compared with patients with Wt/Wt type and Wt/*10 type,patients with *10 /*10 type had higher risk for 3-year,5-year disease free survival of ER-positive breast cancer patients treated with TAMtherapy.Conclusion The prognosis of *10 /*10 type ER-posi-tive breast cancer patients treated with TAMtherapy is poor,and we can detect CYP2D6 polymorphism before TAMtherapy to use drug rationally.关键词
乳腺癌/细胞色素P4502D6/基因多态性/他莫昔芬/雌激素受体Key words
breast carcinoma/cytochrome P4502D6/gene polymorphism/tamoxifen/estrogen receptor分类
医药卫生引用本文复制引用
于洋,尤伟,梁栋,吕峰,杨秦蘅,张斌..CYP2D6基因多态性对接受他莫昔芬治疗ER 阳性乳腺癌患者预后的影响[J].山东医药,2016,56(42):17-20,4.基金项目
河南省科技计划项目（142300410388）。 （）
