应用化学2016，Vol.33Issue(11)：1289-1294,6.DOI:10.11944/j.issn.1000-0518.2016.11.160026
铜催化肟酯与苄醇构建多取代吡啶
Synthesis of Pyridines via Copper-catalyzed Reaction of Oxime Acetates with Benzyl Alcohols
摘要
Abstract
Pyridine derivatives were synthesized in a one-pot reaction from oxime acetates and benzyl alcohols in the presence of copper (Ⅱ) trifluoromethanesulfonate [Cu(OTf)2] catalyst.The effect of catalysts and their dosage , raw material ratios, solvents, and temperatures on the yield were investigated .The target compound 2, 4, 6-trisubstituted pyridine was obtained in 88% yield under the optimum condition .The molecular structures of products were analyzed by mass spectrometry and nuclear magnetic resonance spectroscopy ( 1 H NMR and 13 C NMR) .The method has several advantages:commerically available materials , easy operation , mild reaction conditions , good yields and a wide range of functional group tolerance .关键词
肟酯/苄醇/铜催化/吡啶衍生物/一锅法Key words
oxime acetate/benzyl alcohol/copper-catalyzed/pyridine derivative/one-pot reaction分类
化学化工引用本文复制引用
石赟,任超杰,张宁..铜催化肟酯与苄醇构建多取代吡啶[J].应用化学,2016,33(11):1289-1294,6.基金项目
国家科学自然基金（21102663）、甘肃省青年科技基金计划（1107RJYA080）资助项目Supported by National Natural Science Foundation of China （ No．21101663）， Gansu Province Youth Science and Technology Fund Project （）
