中国临床医学2016，Vol.23Issue(5)：570-575,6.DOI:10.12025/j.issn.1008-6358.2016.20160103
生长因子受体结合蛋白2表达与结直肠癌进展和预后的相关性
The relationship between growth factor receptor-bound protein 2 expression and the progression and prognosis of colorectal cancer
摘要
Abstract
Objective:To evaluate the correlation between growth factor receptor-bound protein 2 (Grb2 )expression and the progression and prognosis of colorectal cancer. Methods:Grb2 expression and its location were detected by immunohistochemisty.The relationship between Grb2 expression and clinicopathologic factors (including age,sex,tumor location, differentiation grade, number of metastatic lymph nodes, TNM staging, adjuvant chemotherapy, serum carcinoembryonic antigen (CEA)and serum CA1 9-9 were analyzed by t-test,chi-square test and so on.Kaplan-Meier method was used to analyze the influence of Grb2 expression on the survival rate of patients,and Cox regression analysis was used to analyze factors contributing to prognosis of colorectal cancer.Results:Grb2 was mainly expressed in the cytoplasm of colorectal cancer epithelial cells.The expression of cytoplasmic Grb2 in colorectal cancer was significantly higher than that in adenoma and adjacent tissues (P<0.05),while there was no significant difference in nucleic Grb2.There was no correlation between cytoplasmic Grb2 expression and such clinicopathologic factors as age,sex,tumor location,differentiation grade, TNM staging,adj uvant chemotherapy,serum CEA and serum CA1 9-9 ,but correlation between Grb2 expression and the number of metastatic lymph nodes(P= 0.001).Cox univariate analysis showed that high expression of cytoplasmic Grb2 may predict poor prognosis;after indices such as TNM were included,Cox multivariate analysis showed that Grb2 is an independent prognostic factor for colorectal cancer:its high expression predicted a shorter disease-free survival (HR= 2.664,P= 0.015) and overall survival (HR= 2.574,P= 0.019).Conclusions:The high expression of Grb2 is closely related to the progression of colorectal cancer,and it is an independent risk factor for colorectal cancer prognosis.关键词
结直肠癌/生长因子受体结合蛋白2/不良预后Key words
colorectal cancer/growth factor receptor-bound protein 2/poor prognosis分类
医药卫生引用本文复制引用
康争春,梁涵,李勃,刘岩,蔡慧,马立业..生长因子受体结合蛋白2表达与结直肠癌进展和预后的相关性[J].中国临床医学,2016,23(5):570-575,6.基金项目
国家自然科学基金青年科学基金（81402433），中国博士后科学基金（2015T81088）．Supported by National Natural Youth Science Foundation of China（81402433），and China Postdoctoral Science Foundation（2015T81088）． （）
