中国临床医学2016，Vol.23Issue(5)：576-580,5.DOI:10.12025/j.issn.1008-6358.2016.20160918
ERCC1和TUBB3在卵巢癌组织中的表达及其临床意义
Expression and significance of ERCC1 and TUBB3 in ovarian carcinoma
李励 1刘胜楠 1郑唯强 2张俊洁1
作者信息
- 1. 第二军医大学附属长海医院妇产科，上海 200433
- 2. 第二军医大学附属长海医院病理科，上海 200433
- 折叠
摘要
Abstract
Objective:To study the expressions and significance of ERCC1 and TUBB3 in epithelial ovarian cancer. Methods:By using suspension array technology,the mRNA expression of ERCC1 and TUBB3 in 48 ovarian specimens was analyzed.The correlationship between mRNA expression and patients’clinical data,serum tumor marker,pathological types and the effectiveness of the recent chemotherapy were statistically analyzed.Results:The expression of ERCC1 is correlated with the surgical-pathological staging,and it is increasing along with the stage increasing (P<0.05 ).The expression of ERCC1 is positively correlated with the expression of TUBB3 and P53 protein(P= 0.002,r= 0.438;P= 0.004,r= 0.414). The effectiveness of chemotherapy was statistically higher when ERCC1 expression is negative(P= 0.006).Conclusions:The differential expression of ERCC1 in different stages of epithelial ovarian cancer is indicating the ERCC1 maybe participated in the development process of ovarian cancer,and it can evaluate the malignant degrees of ovarian carcinoma.ERCC1 and TUBB3 have similarity in indicating the epithelial ovarian cancer,and they are related to the occurrence,development and prognosis of ovarian carcinoma.ERCC1 and P5 3 may be related to the prognosis of ovarian carcinoma,and it can be an independent prognosis factor.ERCC1 expression intensity could affect the recent sensitivity of chemotherapy of patients with ovarian carcinoma.All in all,ERCC1 and TUBB3 may be the effective indicators of judging malignant degree of ovarian carcinoma,and it may also help predicting the effectiveness of chemotherapy and long-term prognosis.关键词
上皮性卵巢癌/ERCC1基因/TUBB3基因/液相芯片技术法Key words
epithelial ovarian cancer/ERCC1 gene/TUBB3 gene/suspension array technology分类
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李励,刘胜楠,郑唯强,张俊洁..ERCC1和TUBB3在卵巢癌组织中的表达及其临床意义[J].中国临床医学,2016,23(5):576-580,5.
