中国临床医学2016，Vol.23Issue(5)：656-661,6.DOI:10.12025/j.issn.1008-6358.2016.20160296
可溶性纤维介素2的免疫调节作用研究进展
Research progress on the role of soluble fibrinogen-like protein 2 in immunoregulation
彭博 1戎瑞明 2许明 1朱同玉2
作者信息
- 1. 复旦大学附属中山医院泌尿外科，上海200032
- 2. 上海市器官移植重点实验室，上海200032
- 折叠
摘要
Abstract
Soluble fibrinogen-like protein 2 (sFGL2 ),or fibroleukin,is an effector secreted by the regulatory T cells (Treg)and plays an important role in immunoregulation.It is critical for the maintenance of the activity and function of Treg, and can suppress the maturation of dendritic cells,induce the apoptosis of B cells and suppress the activation and proliferation of T cells through the FcγRIIB receptor,so that it is a promising drug for prevention and treatment of rej ection,and induction of immune tolerance.This review concluded the recent progress of immunoregulatory research of sFGL2,including its structure and receptor,its effects on T cells and antigen presenting cells,its signaling pathway,its relationship with organ transplantation and its possibility for clinic use.关键词
可溶性纤维介素2/调节性T细胞/免疫调节/器官移植Key words
soluble fibrinogen-like protein 2 (sFGL2 )/regulatory T cells/immunoregulation/organ transplantation分类
医药卫生引用本文复制引用
彭博,戎瑞明,许明,朱同玉..可溶性纤维介素2的免疫调节作用研究进展[J].中国临床医学,2016,23(5):656-661,6.
