中国临床医学2016，Vol.23Issue(5)：672-676,5.DOI:10.12025/j.issn.1008-6358.2016.20160519
原发免疫性血小板减少症中调节性T淋巴细胞的异常
Abnormalities of regulatory T lymphocytes in primary immune thrombocytopenia
卢雨萌 1程韵枫1
作者信息
- 1. 复旦大学附属中山医院血液科，上海 200032
- 折叠
摘要
Abstract
Primary immune thrombocytopenia is a kind of autoimmune disease,characterized by decreased platelets and an increased risk of bleeding.Besides destruction of platelet by platelet specific antibodies produced by auto-reactive B cells and the imbalance of Th1/Th2 cells,the study of regulatory T lymphocytes is getting more and more attention.Regulatory T lymphocytes are a subset of CD4+T lymphocytes that can suppress immune response.However,recent studies have discovered that a sublineage of CD8+regulatory T lymphocytes is also associated with the pathogenesis and treatment of ITP.This review focuses on the role of abnormalities in the number and function of regulatory T lymphocytes in the pathogenesis of ITP.关键词
免疫性血小板减少症/发病机制/调节性T淋巴细胞Key words
immune thrombocytopenia/pathogenesis/regulatory T lymphocytes分类
医药卫生引用本文复制引用
卢雨萌,程韵枫..原发免疫性血小板减少症中调节性T淋巴细胞的异常[J].中国临床医学,2016,23(5):672-676,5.
