中国免疫学杂志2016，Vol.32Issue(11)：1569-1572,4.DOI:10.3969/j.issn.1000-484X.2016.11.001
TSLPR抗体抑制ApoE敲除小鼠动脉粥样硬化血栓形成
TSLPR antibody inhibits platelet function and atherothrombosis in ApoE-/-mice
摘要
Abstract
Objective:To explore the role of TSLPR antibody in the atherothrombosis inhibition.Methods: 8 weeks old ApoE-/-mice were fed with high-cholesterol diet for 12 weeks.During this time,mice in different groups were injected periodically with TSLPR antibody or isotype IgG respectively.The time of atherothrombosis ,platelet aggregation function ,platelet release function ,and the expression of platelet membrane glycoprotein in different groups were detected.Results:Compared with those in the IgG control group , in the TSLPR antibody group the time of atherothrombosis was prolonged ,the function of platelet aggregation and release was weakened , the expression of CD62p,CD63,PAC-1 was decreased,the expression of CD42b was increased.Conclusion:TSLPR antibody injection could inhibit atherosclerosis thrombus formation via weakening platelet aggregation and release function and repressing platelet activa -tion.关键词
TSLPR抗体/动脉粥样硬化/动脉粥样硬化血栓形成/血小板Key words
TSLPR antibody/Atherosclerosis/Atherothrombosis/Platelet分类
医药卫生引用本文复制引用
王博远,吴纯,何少林,黄恺,李大主..TSLPR抗体抑制ApoE敲除小鼠动脉粥样硬化血栓形成[J].中国免疫学杂志,2016,32(11):1569-1572,4.基金项目
本文受国家自然科学基金（81170258）和湖北省自然科学基金重点项目资助。 （）
