Abstract
Objective To explore clinical effects of acupuncture with liuwei dihuang pill on type 2 diabetes lipidmetabolic disorder and to investigate its influence on insulin resistance.Methods 225 patients with type 2 diabetes lipidmetabolic disorder who received treatment in Chun′an Chinese Traditional Medicine Hospital from June 2013 to March 2014 were selected, and were divided into 5 groups———groups of A, B, C, D and E by random number table method, 45 cases per group.Patients in group A were given conventional treatment, based on which patients in group B took liuwei dihuang pill orally and patients in group C accepted acupuncture therapy, group D based on group A′s method took liuwei dihuang pill orally combined with acupuncture therapy, and group E used the same method as group D except for taking rosuvastatin capsule orally.Four weeks were taken as a course of treatment, and three courses of treatment was given to patients in the five groups.The <br> related laboratory test index, blood rheology index, and traditional Chinese medicine syndrome score were compared among the five groups before and after the treatment.Results A total of 215 patients finished the treatment as required. ( 1 ) Before treatment, there was no significant difference in fasting plasma glucose (FPG), 2 h postprandial glucose (2 hPG), glycated hemoglobin (HbA1c), insulin resistance index (Homa -IR) of patients in five groups (P >0.05) .There was significant difference in FPG, 2 hPG, HbA1c, and Homa-IR of patients in five groups after treatment (P<0.05); of which Homa-IR of patients in group B was significantly lower than that in group A ( P <0.05 ); Homa -IR of patients in group C was significantly lower than that in group A and B (P<0.05); FPG, 2 hPG, HbA1c, Homa-IR of patients in group D and E were significantly lower than those in group A, B, and C (P<0.05) .(2) Before treatment, there was no significant difference in total cholesterol ( TC ) , triglyceride ( TG ) , low density lipoprotein cholesterol ( LDL-C ) , and high density lipoprotein cholesterol (HDL-C) of patients in five groups (P>0.05) .There was significant difference in TC, TG, LDL-C, and HDL-C of patients in five groups after treatment ( P <0.05 ); of which TC, TG and LDL-C of patients in group B and C were significantly lower than those in group A, while their HDL-C was significantly higher than that in group A ( P<0.05); TC, TG and LDL-C of patients in group D and E were significantly lower than those in group A, B and C, while their HDL-C was significantly higher than that in group A, B and C (P<0.05) .(3) Before treatment, there was no significant difference in whole blood viscosity, plasma viscosity, fibrinogen, and hematocrit of patients in five groups ( P >0.05 ) .There was significant difference in whole blood viscosity, plasma viscosity, fibrinogen and hematocrit of patients in five groups after treatment ( P<0.05); of which whole blood viscosity, plasma viscosity, fibrinogen and hematocrit of patients in group C, D and E were lower than those in group A and B ( P<0.05 ) . ( 4 ) Before treatment, there was no significant difference in traditional Chinese medicine syndrome score of patients in five groups ( P>0.05) .there was significant difference in traditional Chinese medicine syndrome score of patients in five groups after treatment (P<0.05); of which the traditional Chinese medicine syndrome score of patients in group B and C was significantly lower than that in group A ( P<0.05 ); the traditional Chinese medicine syndrome score of patients in group D and E was significantly lower than that in group A, B and C ( P <0.05 ) .Conclusion Acupuncture with liuwei dihuang pill can effectively lower the blood glucose level of patients with type 2 diabetes lipidmetabolic disorder, and can adjust dyslipidemia, reduce blood viscosity, improve status of insulin resistance.It also can be used alone without combining with conventional treatment of Western medicine.关键词
糖尿病,2型/脂代谢障碍/针刺/六味地黄汤/治疗结果/胰岛素抵抗Key words
Diabetes mellitus, type 2/Lipid metabolism disorders/Acupuncture/Liuwei dihuang decoction/Treatment outcome/Insulin resistance分类
医药卫生
